人 DSC2 抗体对
01AB01109
Desmocollin 2 (DSC2) is a calcium-dependent glycoprotein and a member of the cadherin superfamily, primarily functioning as a key component of desmosomes—specialized cell-cell junctions that provide mechanical strength and stability to tissues by linking adjacent cells together. Structurally, DSC2 contains five N-terminal extracellular domains, a transmembrane domain, and a C-terminal cytoplasmic tail, enabling it to interact with desmoglein family members and plakoglobin, and it undergoes posttranslational modifications such as N-glycosylation and O-mannosylation. DSC2 is ubiquitously expressed in desmosomal tissues like skin epithelia and is the only desmocollin isoform present in cardiac muscle, where it localizes to intercalated discs and is essential for maintaining cardiac tissue integrity. Mutations in the DSC2 gene disrupt desmosome structure and function, leading to impaired cell adhesion and are causally linked to arrhythmogenic right ventricular cardiomyopathy and other disorders affecting the heart, skin, and hair.
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技术参数
- 靶点基因名
- DSC2
- 基因别名
- CDHF2; DSC3
- 蛋白别名
- desmocollin 2; DSC2
- UniProt
- Q02487
- 物种
- Human
产品详情
- 靶点名称
- DSC2
- 蛋白名称
- desmocollin 2
- 蛋白别名
- Desmocollin-2; Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
- 靶点基因名
- DSC2
- 基因别名
- CDHF2; DSC3
- UniProt
- Q02487
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Desmocollin 2 (DSC2) is a calcium-dependent glycoprotein and a member of the cadherin superfamily, primarily functioning as a key component of desmosomes—specialized cell-cell junctions that provide mechanical strength and stability to tissues by linking adjacent cells together. Structurally, DSC2 contains five N-terminal extracellular domains, a transmembrane domain, and a C-terminal cytoplasmic tail, enabling it to interact with desmoglein family members and plakoglobin, and it undergoes posttranslational modifications such as N-glycosylation and O-mannosylation. DSC2 is ubiquitously expressed in desmosomal tissues like skin epithelia and is the only desmocollin isoform present in cardiac muscle, where it localizes to intercalated discs and is essential for maintaining cardiac tissue integrity. Mutations in the DSC2 gene disrupt desmosome structure and function, leading to impaired cell adhesion and are causally linked to arrhythmogenic right ventricular cardiomyopathy and other disorders affecting the heart, skin, and hair.