人 DRAXIN 抗体对
01AB01108
Dorsal inhibitory axon guidance protein (DRAXIN) is a secreted, 58 kDa glycosylated protein primarily expressed in the developing brain and spinal cord, where it functions as a chemorepulsive axon guidance molecule essential for neural circuit formation, including the spinal cord commissure, corpus callosum, and thalamocortical projections. Structurally, DRAXIN contains a signal sequence, a mature domain with a cysteine-rich region, and shares similarities with the DKK family of Wnt inhibitors, acting as a Wnt antagonist by binding to LRP6. It interacts with receptors such as DCC and Neo1, influencing axon pathfinding by inhibiting or repelling neurite outgrowth from dorsal spinal cord neurons and regulating the remodeling of midline structures necessary for commissural axon crossing. Disruption of DRAXIN function has been linked to abnormal neural development, particularly affecting the formation of the corpus callosum, which can result in neurodevelopmental disorders due to impaired axon guidance and midline crossing.
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技术参数
- 靶点基因名
- DRAXIN
- 基因别名
- C1orf187
- 蛋白别名
- dorsal inhibitory axon guidance protein; DRAXIN
- UniProt
- Q8NBI3
- 物种
- Human
产品详情
- 靶点名称
- DRAXIN
- 蛋白名称
- dorsal inhibitory axon guidance protein
- 蛋白别名
- Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin
- 靶点基因名
- DRAXIN
- 基因别名
- C1orf187
- UniProt
- Q8NBI3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dorsal inhibitory axon guidance protein (DRAXIN) is a secreted, 58 kDa glycosylated protein primarily expressed in the developing brain and spinal cord, where it functions as a chemorepulsive axon guidance molecule essential for neural circuit formation, including the spinal cord commissure, corpus callosum, and thalamocortical projections. Structurally, DRAXIN contains a signal sequence, a mature domain with a cysteine-rich region, and shares similarities with the DKK family of Wnt inhibitors, acting as a Wnt antagonist by binding to LRP6. It interacts with receptors such as DCC and Neo1, influencing axon pathfinding by inhibiting or repelling neurite outgrowth from dorsal spinal cord neurons and regulating the remodeling of midline structures necessary for commissural axon crossing. Disruption of DRAXIN function has been linked to abnormal neural development, particularly affecting the formation of the corpus callosum, which can result in neurodevelopmental disorders due to impaired axon guidance and midline crossing.