人 DPPA4 抗体对
01AB00219
Developmental pluripotency associated 4 (DPPA4) is a crucial transcription factor involved in maintaining pluripotency in embryonic stem cells (ESCs). It is highly expressed in ESCs and plays a significant role in self-renewal and pluripotency sustainability. DPPA4 overexpression has been shown to inhibit differentiation and promote proliferation in ESCs by regulating genes involved in the G1/S transition and modulating chromatin structure. In cancer, DPPA4 is re-expressed in several malignant tumors, including colon cancer, and is identified as a new pluripotency-related oncogene. Its upregulation is correlated with poor prognosis and metastasis in colon cancer patients. DPPA4 primarily associates with active chromatin domains and influences chromatin modifications at target genes.
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技术参数
- 靶点基因名
- DPPA4
- 蛋白别名
- developmental pluripotency associated 4; DPPA4
- UniProt
- Q7L190
- 物种
- Human
产品详情
- 靶点名称
- DPPA4
- 蛋白名称
- developmental pluripotency associated 4
- 蛋白别名
- Developmental pluripotency-associated protein 4
- 靶点基因名
- DPPA4
- UniProt
- Q7L190
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Developmental pluripotency associated 4 (DPPA4) is a crucial transcription factor involved in maintaining pluripotency in embryonic stem cells (ESCs). It is highly expressed in ESCs and plays a significant role in self-renewal and pluripotency sustainability. DPPA4 overexpression has been shown to inhibit differentiation and promote proliferation in ESCs by regulating genes involved in the G1/S transition and modulating chromatin structure. In cancer, DPPA4 is re-expressed in several malignant tumors, including colon cancer, and is identified as a new pluripotency-related oncogene. Its upregulation is correlated with poor prognosis and metastasis in colon cancer patients. DPPA4 primarily associates with active chromatin domains and influences chromatin modifications at target genes.