人 DPF2 抗体对
01AB02164
Double PHD fingers 2 (DPF2), also known as BAF45d, is a nuclear chromatin-associated protein that serves as an epigenetic reader within the SWI/SNF (BAF) remodeling complex. It contains a tandem double PHD finger motif that specifically recognizes and binds to modified histone H3 N-terminal tails, thereby facilitating the regulation of gene transcription, apoptosis, and NF-kappaB-dependent inflammatory responses. Clinically, DPF2 is implicated in hematologic malignancies, with recurrent gene rearrangements and altered expression observed in acute myeloid leukemia. Furthermore, germline variants in DPF2 have been associated with distinct neurodevelopmental and immunologic phenotypes, suggesting that it plays a dosage-sensitive role in both development and immune system function. Its ability to link chromatin modification to transcriptional output makes it a key regulator of cellular identity and homeostasis.
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技术参数
- 靶点基因名
- DPF2
- 基因别名
- BAF45D; REQ; UBID4
- 蛋白别名
- double PHD fingers 2; DPF2
- UniProt
- Q92785
- 物种
- Human
产品详情
- 靶点名称
- DPF2
- 蛋白名称
- double PHD fingers 2
- 蛋白别名
- Zinc finger protein ubi-d4; Apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4; zinc and double PHD fingers family 2; Protein requiem
- 靶点基因名
- DPF2
- 基因别名
- BAF45D; REQ; UBID4
- UniProt
- Q92785
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Double PHD fingers 2 (DPF2), also known as BAF45d, is a nuclear chromatin-associated protein that serves as an epigenetic reader within the SWI/SNF (BAF) remodeling complex. It contains a tandem double PHD finger motif that specifically recognizes and binds to modified histone H3 N-terminal tails, thereby facilitating the regulation of gene transcription, apoptosis, and NF-kappaB-dependent inflammatory responses. Clinically, DPF2 is implicated in hematologic malignancies, with recurrent gene rearrangements and altered expression observed in acute myeloid leukemia. Furthermore, germline variants in DPF2 have been associated with distinct neurodevelopmental and immunologic phenotypes, suggesting that it plays a dosage-sensitive role in both development and immune system function. Its ability to link chromatin modification to transcriptional output makes it a key regulator of cellular identity and homeostasis.