人 Dopamine beta Hydroxylase 抗体对
01AB04006
Dopamine beta-hydroxylase (DBH) is a copper-containing enzyme that catalyzes the conversion of dopamine to norepinephrine, playing a vital role in catecholamine biosynthesis. This enzyme, which is approximately 290 kDa and composed of four identical subunits, requires ascorbate as a cofactor for its activity. DBH is primarily expressed in noradrenergic neurons of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. Mutations or deficiencies in DBH can lead to dopamine beta-hydroxylase deficiency, a rare disorder characterized by low norepinephrine levels, resulting in symptoms such as orthostatic hypotension and impaired stress response. Additionally, variations in DBH activity have been implicated in psychiatric conditions such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and substance use disorders like alcoholism.
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技术参数
- 靶点基因名
- DBH
- 蛋白别名
- dopamine beta-hydroxylase; Dopamine beta Hydroxylase
- UniProt
- P09172
- 物种
- Human
产品详情
- 靶点名称
- Dopamine beta Hydroxylase
- 蛋白名称
- dopamine beta-hydroxylase
- 蛋白别名
- Dopamine beta-hydroxylase; Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]
- 靶点基因名
- DBH
- UniProt
- P09172
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dopamine beta-hydroxylase (DBH) is a copper-containing enzyme that catalyzes the conversion of dopamine to norepinephrine, playing a vital role in catecholamine biosynthesis. This enzyme, which is approximately 290 kDa and composed of four identical subunits, requires ascorbate as a cofactor for its activity. DBH is primarily expressed in noradrenergic neurons of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. Mutations or deficiencies in DBH can lead to dopamine beta-hydroxylase deficiency, a rare disorder characterized by low norepinephrine levels, resulting in symptoms such as orthostatic hypotension and impaired stress response. Additionally, variations in DBH activity have been implicated in psychiatric conditions such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and substance use disorders like alcoholism.