人 DOPA Decarboxylase 抗体对
01AB02572
Dopa decarboxylase (DOPA Decarboxylase) is a pyridoxal 5'-phosphate-dependent enzyme essential for the synthesis of the biogenic amines dopamine and serotonin. It functions as a homodimer, catalyzing the decarboxylation of L-DOPA and L-5-hydroxytryptophan in the brain, peripheral nervous system, and kidneys. The enzyme's activity is tightly regulated by phosphorylation and receptor-mediated signaling to maintain neurotransmitter balance. Clinically, a genetic deficiency in Dopa decarboxylase leads to aromatic L-amino acid decarboxylase deficiency, a severe neurometabolic disorder characterized by developmental delay and movement disorders. Furthermore, dysregulation of this enzyme is a central feature of Parkinson's disease, where its role in converting therapeutic L-DOPA into dopamine is critical for symptom management.
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技术参数
- 靶点基因名
- DDC
- 基因别名
- AADC
- 蛋白别名
- dopa decarboxylase; DOPA Decarboxylase
- UniProt
- P20711
- 物种
- Human
产品详情
- 靶点名称
- DOPA Decarboxylase
- 蛋白名称
- dopa decarboxylase
- 蛋白别名
- Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC
- 靶点基因名
- DDC
- 基因别名
- AADC
- UniProt
- P20711
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dopa decarboxylase (DOPA Decarboxylase) is a pyridoxal 5'-phosphate-dependent enzyme essential for the synthesis of the biogenic amines dopamine and serotonin. It functions as a homodimer, catalyzing the decarboxylation of L-DOPA and L-5-hydroxytryptophan in the brain, peripheral nervous system, and kidneys. The enzyme's activity is tightly regulated by phosphorylation and receptor-mediated signaling to maintain neurotransmitter balance. Clinically, a genetic deficiency in Dopa decarboxylase leads to aromatic L-amino acid decarboxylase deficiency, a severe neurometabolic disorder characterized by developmental delay and movement disorders. Furthermore, dysregulation of this enzyme is a central feature of Parkinson's disease, where its role in converting therapeutic L-DOPA into dopamine is critical for symptom management.