抗人 DOHH 抗体对
01AB03858
Deoxyhypusine hydroxylase (DOHH) is a crucial enzyme involved in the post-translational modification of the eukaryotic translation initiation factor 5A (eIF5A), specifically catalyzing the hydroxylation of deoxyhypusine to form hypusine. This modification is essential for eIF5A's role in protein synthesis and cell proliferation. DOHH is a nonheme diiron monooxygenase, characterized by its ability to activate molecular oxygen for substrate hydroxylation, and features a stable peroxo-diiron(III) intermediate that has been crystallized for structural studies. Mutations in the DOHH gene have been linked to neurodevelopmental disorders, highlighting its importance in cellular processes and development. The enzyme's activity is also considered a potential therapeutic target for various diseases, including cancer and metabolic disorders, due to its role in regulating eIF5A function and cellular growth pathways.
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技术参数
- 靶点基因名
- DOHH
- 基因别名
- HLRC1
- 蛋白别名
- deoxyhypusine hydroxylase; DOHH
- UniProt
- Q9BU89
- 物种
- Human
产品详情
- 靶点名称
- DOHH
- 蛋白名称
- deoxyhypusine hydroxylase
- 蛋白别名
- Deoxyhypusine hydroxylase; hDOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase; HEAT-like repeat-containing protein 1
- 靶点基因名
- DOHH
- 基因别名
- HLRC1
- UniProt
- Q9BU89
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Deoxyhypusine hydroxylase (DOHH) is a crucial enzyme involved in the post-translational modification of the eukaryotic translation initiation factor 5A (eIF5A), specifically catalyzing the hydroxylation of deoxyhypusine to form hypusine. This modification is essential for eIF5A's role in protein synthesis and cell proliferation. DOHH is a nonheme diiron monooxygenase, characterized by its ability to activate molecular oxygen for substrate hydroxylation, and features a stable peroxo-diiron(III) intermediate that has been crystallized for structural studies. Mutations in the DOHH gene have been linked to neurodevelopmental disorders, highlighting its importance in cellular processes and development. The enzyme's activity is also considered a potential therapeutic target for various diseases, including cancer and metabolic disorders, due to its role in regulating eIF5A function and cellular growth pathways.