抗人 Dnmt3b 抗体对
01AB02818
DNA methyltransferase 3 beta (Dnmt3b) is an enzyme essential for establishing de novo DNA methylation patterns during mammalian embryonic development. It catalyzes the transfer of methyl groups to cytosine residues in CpG dinucleotides, a process critical for gene silencing and genomic stability. DNMT3B contains a PWWP domain that guides it to specific chromatin regions by binding H3K36me3 marks. It functions cooperatively with DNMT3A and DNMT3L. Pathogenic mutations in DNMT3B cause immunodeficiency-centromere instability-facial anomalies (ICF) syndrome, a disorder characterized by hypomethylation of pericentromeric heterochromatin, immune defects, and developmental abnormalities.
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技术参数
- 靶点基因名
- DNMT3B
- 蛋白别名
- DNA methyltransferase 3 beta; Dnmt3b
- UniProt
- Q9UBC3
- 物种
- Human
产品详情
- 靶点名称
- Dnmt3b
- 蛋白名称
- DNA methyltransferase 3 beta
- 蛋白别名
- DNA; cytosine-5)-methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB
- 靶点基因名
- DNMT3B
- UniProt
- Q9UBC3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DNA methyltransferase 3 beta (Dnmt3b) is an enzyme essential for establishing de novo DNA methylation patterns during mammalian embryonic development. It catalyzes the transfer of methyl groups to cytosine residues in CpG dinucleotides, a process critical for gene silencing and genomic stability. DNMT3B contains a PWWP domain that guides it to specific chromatin regions by binding H3K36me3 marks. It functions cooperatively with DNMT3A and DNMT3L. Pathogenic mutations in DNMT3B cause immunodeficiency-centromere instability-facial anomalies (ICF) syndrome, a disorder characterized by hypomethylation of pericentromeric heterochromatin, immune defects, and developmental abnormalities.