人 DNAL1 抗体对
01AB02650
Dynein axonemal light chain 1 (DNAL1) is a cytoplasmic protein and a critical component of the outer dynein arm within motile cilia and flagella. It facilitates ATP-dependent ciliary beating and regulates beat frequency by tethering the heavy chain DNAH5 to axonemal microtubules. DNAL1 is essential for mucociliary clearance in the respiratory epithelium, sperm flagellar motility, and the determination of the embryonic left-right axis. Clinically, biallelic loss-of-function variants in DNAL1 cause primary ciliary dyskinesia type 16, a disorder characterized by chronic sinopulmonary infections, bronchiectasis, and male infertility due to immotile sperm. Additionally, DNAL1 has been identified as a microtubule-associated host dependency factor for HIV-1 infection.
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技术参数
- 靶点基因名
- DNAL1
- 基因别名
- C14orf168
- 蛋白别名
- dynein axonemal light chain 1; DNAL1
- UniProt
- Q4LDG9
- 物种
- Human
产品详情
- 靶点名称
- DNAL1
- 蛋白名称
- dynein axonemal light chain 1
- 蛋白别名
- Dynein axonemal light chain 1; LC1
- 靶点基因名
- DNAL1
- 基因别名
- C14orf168
- UniProt
- Q4LDG9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dynein axonemal light chain 1 (DNAL1) is a cytoplasmic protein and a critical component of the outer dynein arm within motile cilia and flagella. It facilitates ATP-dependent ciliary beating and regulates beat frequency by tethering the heavy chain DNAH5 to axonemal microtubules. DNAL1 is essential for mucociliary clearance in the respiratory epithelium, sperm flagellar motility, and the determination of the embryonic left-right axis. Clinically, biallelic loss-of-function variants in DNAL1 cause primary ciliary dyskinesia type 16, a disorder characterized by chronic sinopulmonary infections, bronchiectasis, and male infertility due to immotile sperm. Additionally, DNAL1 has been identified as a microtubule-associated host dependency factor for HIV-1 infection.