人 DNAJB1 抗体对
01AB00216
DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), a member of the DnaJ heat shock protein family (Hsp40), functions primarily as a molecular chaperone, facilitating protein folding and preventing aggregation by stimulating the ATPase activity of Hsp70 proteins. This protein is characterized by a conserved J-domain, which is essential for its interaction with Hsp70, thereby playing a critical role in cellular stress responses and maintaining proteostasis. DNAJB1 is notably implicated in fibrolamellar hepatocellular carcinoma (FL-HCC), a rare and aggressive liver cancer characterized by the oncogenic fusion of DNAJB1 with the PRKACA gene, leading to aberrant protein kinase A activity. Additionally, DNAJB1 has been associated with other diseases, including various hematologic cancers and muscular dystrophies.
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技术参数
- 靶点基因名
- DNAJB1
- 基因别名
- DNAJ1; HDJ1; HSPF1
- 蛋白别名
- DnaJ heat shock protein family (Hsp40) member B1; DNAJB1
- UniProt
- P25685
- 物种
- Human
产品详情
- 靶点名称
- DNAJB1
- 蛋白名称
- DnaJ heat shock protein family (Hsp40) member B1
- 蛋白别名
- DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40; Human DnaJ protein 1; hDj-1
- 靶点基因名
- DNAJB1
- 基因别名
- DNAJ1; HDJ1; HSPF1
- UniProt
- P25685
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), a member of the DnaJ heat shock protein family (Hsp40), functions primarily as a molecular chaperone, facilitating protein folding and preventing aggregation by stimulating the ATPase activity of Hsp70 proteins. This protein is characterized by a conserved J-domain, which is essential for its interaction with Hsp70, thereby playing a critical role in cellular stress responses and maintaining proteostasis. DNAJB1 is notably implicated in fibrolamellar hepatocellular carcinoma (FL-HCC), a rare and aggressive liver cancer characterized by the oncogenic fusion of DNAJB1 with the PRKACA gene, leading to aberrant protein kinase A activity. Additionally, DNAJB1 has been associated with other diseases, including various hematologic cancers and muscular dystrophies.