人 DNAJA2 抗体对
01AB02161
DnaJ heat shock protein family (Hsp40) member A2 (DNAJA2) is a ubiquitously expressed cytosolic co-chaperone that plays a vital role in protein folding, refolding, and cellular proteostasis. It contains a canonical N-terminal J-domain, a glycine/phenylalanine-rich segment, and a cysteine-rich zinc-finger-like region, which allow it to bind unfolded polypeptides and stimulate the ATPase activity of Hsp70/Hsc70. DNAJA2 participates in cellular stress responses and protein trafficking, including Golgi-ER retrograde transport. It also interacts with histone regulatory proteins, suggesting a functional role at the chromatin interface. Clinically, DNAJA2 has been associated with subacute bacterial endocarditis and autoimmune vasculitis, reflecting its involvement in systemic inflammatory and immune response pathways.
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技术参数
- 靶点基因名
- DNAJA2
- 基因别名
- CPR3; HIRIP4
- 蛋白别名
- DnaJ heat shock protein family (Hsp40) member A2; DNAJA2
- UniProt
- O60884
- 物种
- Human
产品详情
- 靶点名称
- DNAJA2
- 蛋白名称
- DnaJ heat shock protein family (Hsp40) member A2
- 蛋白别名
- DnaJ homolog subfamily A member 2; Cell cycle progression restoration gene 3 protein; Dnj3; Dj3; HIRA-interacting protein 4; Renal carcinoma antigen NY-REN-14
- 靶点基因名
- DNAJA2
- 基因别名
- CPR3; HIRIP4
- UniProt
- O60884
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DnaJ heat shock protein family (Hsp40) member A2 (DNAJA2) is a ubiquitously expressed cytosolic co-chaperone that plays a vital role in protein folding, refolding, and cellular proteostasis. It contains a canonical N-terminal J-domain, a glycine/phenylalanine-rich segment, and a cysteine-rich zinc-finger-like region, which allow it to bind unfolded polypeptides and stimulate the ATPase activity of Hsp70/Hsc70. DNAJA2 participates in cellular stress responses and protein trafficking, including Golgi-ER retrograde transport. It also interacts with histone regulatory proteins, suggesting a functional role at the chromatin interface. Clinically, DNAJA2 has been associated with subacute bacterial endocarditis and autoimmune vasculitis, reflecting its involvement in systemic inflammatory and immune response pathways.