抗人 DNAI2 抗体对
01AB03347
Dynein axonemal intermediate chain 2 (DNAI2) is a critical protein component of the outer dynein arm in motile cilia and flagella. It belongs to the dynein intermediate chain family and is essential for the assembly and structural stability of the outer dynein arm, which powers microtubule-based motor activity and ciliary beating. DNAI2 is primarily expressed in the respiratory epithelium and sperm flagella, where it ensures proper ciliary motility and left-right patterning during development. Pathogenically, biallelic loss-of-function mutations in DNAI2 are a known cause of primary ciliary dyskinesia type 9 (PCD9). This condition is characterized by immotile or dyskinetic cilia, leading to chronic sinopulmonary infections, bronchiectasis, and situs inversus.
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技术参数
- 靶点基因名
- DNAI2
- 蛋白别名
- dynein axonemal intermediate chain 2; DNAI2
- UniProt
- Q9GZS0
- 物种
- Human
产品详情
- 靶点名称
- DNAI2
- 蛋白名称
- dynein axonemal intermediate chain 2
- 蛋白别名
- Dynein axonemal intermediate chain 2; Axonemal dynein intermediate chain 2
- 靶点基因名
- DNAI2
- UniProt
- Q9GZS0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dynein axonemal intermediate chain 2 (DNAI2) is a critical protein component of the outer dynein arm in motile cilia and flagella. It belongs to the dynein intermediate chain family and is essential for the assembly and structural stability of the outer dynein arm, which powers microtubule-based motor activity and ciliary beating. DNAI2 is primarily expressed in the respiratory epithelium and sperm flagella, where it ensures proper ciliary motility and left-right patterning during development. Pathogenically, biallelic loss-of-function mutations in DNAI2 are a known cause of primary ciliary dyskinesia type 9 (PCD9). This condition is characterized by immotile or dyskinetic cilia, leading to chronic sinopulmonary infections, bronchiectasis, and situs inversus.