人 DLGAP4 抗体对
01AB01102
DLG associated protein 4 (DLGAP4), also known as SAPAP-4, is a membrane-associated guanylate kinase predominantly found at the postsynaptic density of neuronal cells, where it plays a crucial role in synaptic organization and neuronal signaling. DLGAP4 functions as a scaffold protein, interacting with key synaptic proteins such as PSD-95 and potassium channels, and is involved in clustering these molecules at the postsynaptic density, thereby facilitating efficient synaptic transmission and plasticity. It also participates in the organization of adherens junction components and actin cytoskeleton dynamics, which are essential for neuronal migration and the maintenance of radial glial cell structure during brain development. Multiple alternatively spliced isoforms of DLGAP4 exist, reflecting its diverse roles in the nervous system. Clinically, DLGAP4 has been implicated in disease contexts such as hepatocellular carcinoma, where its expression serves as a prognostic marker and is closely linked to tumor progression, and its dysfunction has been associated with defects in neuronal migration and cortical development.
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技术参数
- 靶点基因名
- DLGAP4
- 基因别名
- DAP4; KIAA0964; SAPAP4
- 蛋白别名
- DLG associated protein 4; DLGAP4
- UniProt
- Q9Y2H0
- 物种
- Human
产品详情
- 靶点名称
- DLGAP4
- 蛋白名称
- DLG associated protein 4
- 蛋白别名
- Disks large-associated protein 4; DAP-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4
- 靶点基因名
- DLGAP4
- 基因别名
- DAP4; KIAA0964; SAPAP4
- UniProt
- Q9Y2H0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DLG associated protein 4 (DLGAP4), also known as SAPAP-4, is a membrane-associated guanylate kinase predominantly found at the postsynaptic density of neuronal cells, where it plays a crucial role in synaptic organization and neuronal signaling. DLGAP4 functions as a scaffold protein, interacting with key synaptic proteins such as PSD-95 and potassium channels, and is involved in clustering these molecules at the postsynaptic density, thereby facilitating efficient synaptic transmission and plasticity. It also participates in the organization of adherens junction components and actin cytoskeleton dynamics, which are essential for neuronal migration and the maintenance of radial glial cell structure during brain development. Multiple alternatively spliced isoforms of DLGAP4 exist, reflecting its diverse roles in the nervous system. Clinically, DLGAP4 has been implicated in disease contexts such as hepatocellular carcinoma, where its expression serves as a prognostic marker and is closely linked to tumor progression, and its dysfunction has been associated with defects in neuronal migration and cortical development.