人 DKKL1 抗体对
01AB02153
Dickkopf like acrosomal protein 1 (DKKL1) is a secreted, cysteine-rich glycoprotein belonging to the Dickkopf family, primarily expressed in the testis. It localizes to the acrosome of developing spermatids and mature sperm, where it plays an essential role in acrosome formation and fertilization. Functional studies indicate that DKKL1 facilitates sperm penetration of the zona pellucida and may regulate spermatocyte apoptosis to control sperm output. Additionally, it has been suggested to modulate testosterone synthesis in Leydig cells. Given its specialized expression and function in the male reproductive system, DKKL1 is a key factor in testicular development and spermatogenesis. Clinically, alterations in DKKL1 function or expression are proposed as potential contributors to male infertility, highlighting its importance in reproductive health.
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技术参数
- 靶点基因名
- DKKL1
- 基因别名
- SGY1
- 蛋白别名
- dickkopf like acrosomal protein 1; DKKL1
- UniProt
- Q9UK85
- 物种
- Human
产品详情
- 靶点名称
- DKKL1
- 蛋白名称
- dickkopf like acrosomal protein 1
- 蛋白别名
- Dickkopf-like protein 1; Cancer/testis antigen 34; CT34; Protein soggy-1; SGY-1
- 靶点基因名
- DKKL1
- 基因别名
- SGY1
- UniProt
- Q9UK85
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dickkopf like acrosomal protein 1 (DKKL1) is a secreted, cysteine-rich glycoprotein belonging to the Dickkopf family, primarily expressed in the testis. It localizes to the acrosome of developing spermatids and mature sperm, where it plays an essential role in acrosome formation and fertilization. Functional studies indicate that DKKL1 facilitates sperm penetration of the zona pellucida and may regulate spermatocyte apoptosis to control sperm output. Additionally, it has been suggested to modulate testosterone synthesis in Leydig cells. Given its specialized expression and function in the male reproductive system, DKKL1 is a key factor in testicular development and spermatogenesis. Clinically, alterations in DKKL1 function or expression are proposed as potential contributors to male infertility, highlighting its importance in reproductive health.