人 DKK1 抗体对
01AB01465
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that acts as a potent antagonist of the canonical Wnt/β-catenin signaling pathway. It contains two cysteine-rich domains and functions by binding to LRP5/6 co-receptors, preventing their interaction with Wnt ligands. DKK1 forms a ternary complex with LRP5/6 and Kremen proteins, promoting internalization of LRP5/6 and further inhibiting Wnt signaling. This protein plays crucial roles in embryonic development, including anterior-posterior axial patterning, limb formation, and somitogenesis. In adults, DKK1 is involved in bone homeostasis and stem cell regulation. Dysregulation of DKK1 has been implicated in various diseases, including cancer, where it can act as both a tumor suppressor and promoter depending on the context. Elevated DKK1 levels have been associated with poor prognosis in several cancer types and bone-related disorders like osteoporosis.
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技术参数
- 靶点基因名
- DKK1
- 蛋白别名
- dickkopf WNT signaling pathway inhibitor 1; DKK1
- UniProt
- O94907
- 物种
- Human
产品详情
- 靶点名称
- DKK1
- 蛋白名称
- dickkopf WNT signaling pathway inhibitor 1
- 蛋白别名
- Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK
- 靶点基因名
- DKK1
- UniProt
- O94907
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that acts as a potent antagonist of the canonical Wnt/β-catenin signaling pathway. It contains two cysteine-rich domains and functions by binding to LRP5/6 co-receptors, preventing their interaction with Wnt ligands. DKK1 forms a ternary complex with LRP5/6 and Kremen proteins, promoting internalization of LRP5/6 and further inhibiting Wnt signaling. This protein plays crucial roles in embryonic development, including anterior-posterior axial patterning, limb formation, and somitogenesis. In adults, DKK1 is involved in bone homeostasis and stem cell regulation. Dysregulation of DKK1 has been implicated in various diseases, including cancer, where it can act as both a tumor suppressor and promoter depending on the context. Elevated DKK1 levels have been associated with poor prognosis in several cancer types and bone-related disorders like osteoporosis.