人 DEFB127 抗体对
01AB03446
Defensin beta 127 (DEFB127) is a member of the human beta-defensin family, characterized by a conserved structural domain containing six cysteine residues that form three intramolecular disulfide bonds. This stable framework is essential for its broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses. DEFB127 functions primarily through membrane disruption, the formation of voltage-dependent channels, or interference with microbial metabolism. Beyond its direct microbicidal effects, it exhibits significant immunomodulatory properties, including the induction of chemotaxis via the CCR6 receptor, the inhibition of apoptosis in immune cells, and the regulation of pro-inflammatory cytokines such as TNF-alpha and IL-1beta. By neutralizing lipopolysaccharides and maintaining epithelial homeostasis, DEFB127 serves as a key component of the innate mucosal defense system, protecting host tissues from infection while helping to resolve inflammatory responses.
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技术参数
- 靶点基因名
- DEFB127
- 基因别名
- C20orf73; DEFB27
- 蛋白别名
- defensin beta 127; DEFB127
- UniProt
- Q9H1M4
- 物种
- Human
产品详情
- 靶点名称
- DEFB127
- 蛋白名称
- defensin beta 127
- 蛋白别名
- Beta-defensin 127; Beta-defensin 27; DEFB-27; Defensin; beta 127
- 靶点基因名
- DEFB127
- 基因别名
- C20orf73; DEFB27
- UniProt
- Q9H1M4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Defensin beta 127 (DEFB127) is a member of the human beta-defensin family, characterized by a conserved structural domain containing six cysteine residues that form three intramolecular disulfide bonds. This stable framework is essential for its broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses. DEFB127 functions primarily through membrane disruption, the formation of voltage-dependent channels, or interference with microbial metabolism. Beyond its direct microbicidal effects, it exhibits significant immunomodulatory properties, including the induction of chemotaxis via the CCR6 receptor, the inhibition of apoptosis in immune cells, and the regulation of pro-inflammatory cytokines such as TNF-alpha and IL-1beta. By neutralizing lipopolysaccharides and maintaining epithelial homeostasis, DEFB127 serves as a key component of the innate mucosal defense system, protecting host tissues from infection while helping to resolve inflammatory responses.