抗人 DEFB110 抗体对
01AB03375
Defensin beta 110 (DEFB110) is a cationic antimicrobial peptide and a key component of the innate immune system's first-line defense. As a member of the beta-defensin family, it is characterized by a cysteine-rich sequence stabilized by three intramolecular disulfide bonds that form a distinct beta-strand structure. DEFB110 exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria by interacting with negatively charged microbial membranes. This interaction leads to the formation of pore complexes, resulting in membrane depolarization and cell lysis. Beyond direct microbicidal action, DEFB110 functions as an immunomodulator by recruiting immune cells to sites of infection and participating in wound repair and inflammatory signaling. Produced by epithelial cells and various leukocytes, including macrophages and granulocytes, DEFB110 provides critical protection against a wide range of pathogens, including bacteria, fungi, and enveloped viruses.
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技术参数
- 靶点基因名
- DEFB110
- 基因别名
- DEFB10; DEFB11; DEFB111
- 蛋白别名
- defensin beta 110; DEFB110
- UniProt
- Q30KQ9
- 物种
- Human
产品详情
- 靶点名称
- DEFB110
- 蛋白名称
- defensin beta 110
- 蛋白别名
- Beta-defensin 110; Beta-defensin 10; DEFB-10; Beta-defensin 11; DEFB-11; Beta-defensin 111; Defensin; beta 110; Defensin; beta 111
- 靶点基因名
- DEFB110
- 基因别名
- DEFB10; DEFB11; DEFB111
- UniProt
- Q30KQ9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Defensin beta 110 (DEFB110) is a cationic antimicrobial peptide and a key component of the innate immune system's first-line defense. As a member of the beta-defensin family, it is characterized by a cysteine-rich sequence stabilized by three intramolecular disulfide bonds that form a distinct beta-strand structure. DEFB110 exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria by interacting with negatively charged microbial membranes. This interaction leads to the formation of pore complexes, resulting in membrane depolarization and cell lysis. Beyond direct microbicidal action, DEFB110 functions as an immunomodulator by recruiting immune cells to sites of infection and participating in wound repair and inflammatory signaling. Produced by epithelial cells and various leukocytes, including macrophages and granulocytes, DEFB110 provides critical protection against a wide range of pathogens, including bacteria, fungi, and enveloped viruses.