抗人 DDX49 抗体对
01AB02741
DEAD-box helicase 49 (DDX49) is a nucleolar RNA helicase with robust ATPase and RNA unwinding activity, significantly higher than related helicases, and is essential for efficient export of poly(A)+ RNA from the nucleus in a splicing-independent manner. DDX49 regulates the steady-state levels of pre-ribosomal RNA by controlling its transcription and stability, thereby influencing both mRNA export and ribosome biogenesis, which together modulate global protein translation. It is predominantly localized in the nucleolus and nucleoplasm and is predicted to be involved in rRNA processing and nucleic acid binding. Functionally, DDX49 promotes cell proliferation and colony formation, and its expression is elevated in various cancer types, suggesting a role in oncogenic transformation when dysregulated. Its overexpression is associated with cancer.
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技术参数
- 靶点基因名
- DDX49
- 蛋白别名
- DEAD-box helicase 49; DDX49
- UniProt
- Q9Y6V7
- 物种
- Human
产品详情
- 靶点名称
- DDX49
- 蛋白名称
- DEAD-box helicase 49
- 蛋白别名
- Probable ATP-dependent RNA helicase DDX49; DEAD box protein 49
- 靶点基因名
- DDX49
- UniProt
- Q9Y6V7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DEAD-box helicase 49 (DDX49) is a nucleolar RNA helicase with robust ATPase and RNA unwinding activity, significantly higher than related helicases, and is essential for efficient export of poly(A)+ RNA from the nucleus in a splicing-independent manner. DDX49 regulates the steady-state levels of pre-ribosomal RNA by controlling its transcription and stability, thereby influencing both mRNA export and ribosome biogenesis, which together modulate global protein translation. It is predominantly localized in the nucleolus and nucleoplasm and is predicted to be involved in rRNA processing and nucleic acid binding. Functionally, DDX49 promotes cell proliferation and colony formation, and its expression is elevated in various cancer types, suggesting a role in oncogenic transformation when dysregulated. Its overexpression is associated with cancer.