人 DDAH1 抗体对
01AB03249
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a cytosolic enzyme essential for maintaining vascular homeostasis through the regulation of nitric oxide (NO) signaling. It functions by hydrolyzing asymmetric dimethyl-L-arginine (ADMA) and Nω-monomethyl-L-arginine (MMA), which are endogenous inhibitors of nitric oxide synthase (NOS). By clearing these inhibitors, DDAH1 facilitates the continuous production of NO. Structurally, the protein belongs to the DDAH gene family and forms a characteristic propeller-like fold. Its catalytic mechanism involves a conserved cysteine residue within the active site, which is susceptible to inhibition by endogenous zinc ions (Zn2+). This enzymatic activity is a critical determinant of systemic NO bioavailability and vascular tone.
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技术参数
- 靶点基因名
- DDAH1
- 基因别名
- DDAH
- 蛋白别名
- dimethylarginine dimethylaminohydrolase 1; DDAH1
- UniProt
- O94760
- 物种
- Human
产品详情
- 靶点名称
- DDAH1
- 蛋白名称
- dimethylarginine dimethylaminohydrolase 1
- 蛋白别名
- N(G; N(G)-dimethylarginine dimethylaminohydrolase 1; DDAH-1; Dimethylarginine dimethylaminohydrolase 1; DDAHI; Dimethylargininase-1
- 靶点基因名
- DDAH1
- 基因别名
- DDAH
- UniProt
- O94760
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a cytosolic enzyme essential for maintaining vascular homeostasis through the regulation of nitric oxide (NO) signaling. It functions by hydrolyzing asymmetric dimethyl-L-arginine (ADMA) and Nω-monomethyl-L-arginine (MMA), which are endogenous inhibitors of nitric oxide synthase (NOS). By clearing these inhibitors, DDAH1 facilitates the continuous production of NO. Structurally, the protein belongs to the DDAH gene family and forms a characteristic propeller-like fold. Its catalytic mechanism involves a conserved cysteine residue within the active site, which is susceptible to inhibition by endogenous zinc ions (Zn2+). This enzymatic activity is a critical determinant of systemic NO bioavailability and vascular tone.