抗人 DCUN1D1 抗体对
01AB03333
Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) is a cytosolic and nucleoplasmic adaptor that functions as an accessory E3 ligase within the NEDD8 neddylation pathway. It facilitates the activation of cullin-RING ubiquitin ligases by binding to cullin-RBX1 complexes, the NEDD8-conjugating enzyme UBE2M, and CAND1. This interaction promotes the nuclear translocation of these complexes and enhances cullin neddylation, thereby regulating protein ubiquitination and cell-cycle proteostasis. DCUN1D1 contains a C-terminal PONY domain essential for its E3 activity and an N-terminal UBA domain that serves as a negative feedback regulator. Clinically, DCUN1D1 is frequently amplified and overexpressed in squamous cell carcinomas of the head, neck, and lung. In these contexts, it acts as an oncogene that drives tumor proliferation, invasion, and overall aggressiveness.
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技术参数
- 靶点基因名
- DCUN1D1
- 基因别名
- DCN1; DCUN1L1; RP42; SCCRO
- 蛋白别名
- defective in cullin neddylation 1 domain containing 1; DCUN1D1
- UniProt
- Q96GG9
- 物种
- Human
产品详情
- 靶点名称
- DCUN1D1
- 蛋白名称
- defective in cullin neddylation 1 domain containing 1
- 蛋白别名
- DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene
- 靶点基因名
- DCUN1D1
- 基因别名
- DCN1; DCUN1L1; RP42; SCCRO
- UniProt
- Q96GG9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Defective in cullin neddylation 1 domain containing 1 (DCUN1D1) is a cytosolic and nucleoplasmic adaptor that functions as an accessory E3 ligase within the NEDD8 neddylation pathway. It facilitates the activation of cullin-RING ubiquitin ligases by binding to cullin-RBX1 complexes, the NEDD8-conjugating enzyme UBE2M, and CAND1. This interaction promotes the nuclear translocation of these complexes and enhances cullin neddylation, thereby regulating protein ubiquitination and cell-cycle proteostasis. DCUN1D1 contains a C-terminal PONY domain essential for its E3 activity and an N-terminal UBA domain that serves as a negative feedback regulator. Clinically, DCUN1D1 is frequently amplified and overexpressed in squamous cell carcinomas of the head, neck, and lung. In these contexts, it acts as an oncogene that drives tumor proliferation, invasion, and overall aggressiveness.