人 DCTN2 抗体对
01AB02757
Dynactin subunit 2 (DCTN2), also known as dynamitin, is a critical component of the dynactin complex, which plays an essential role in cellular transport processes, including the movement of organelles and vesicles along microtubules. DCTN2 is involved in various cellular functions such as endocytosis, mitosis, and the positioning of the nucleus. It interacts with cytoplasmic dynein, facilitating the transport of cellular cargoes. Dysregulation of DCTN2 has been linked to several diseases, particularly in cancer, where it has been shown to promote tumor progression. Elevated levels of DCTN2 expression are associated with poor prognosis in various malignancies, including hepatocellular carcinoma (HCC), where it enhances cell proliferation and metastasis by modulating key signaling pathways, such as the AKT pathway.
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技术参数
- 靶点基因名
- DCTN2
- 基因别名
- DCTN50
- 蛋白别名
- dynactin subunit 2; DCTN2
- UniProt
- Q13561
- 物种
- Human
产品详情
- 靶点名称
- DCTN2
- 蛋白名称
- dynactin subunit 2
- 蛋白别名
- Dynactin subunit 2; 50 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; DCTN-50; p50 dynamitin
- 靶点基因名
- DCTN2
- 基因别名
- DCTN50
- UniProt
- Q13561
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dynactin subunit 2 (DCTN2), also known as dynamitin, is a critical component of the dynactin complex, which plays an essential role in cellular transport processes, including the movement of organelles and vesicles along microtubules. DCTN2 is involved in various cellular functions such as endocytosis, mitosis, and the positioning of the nucleus. It interacts with cytoplasmic dynein, facilitating the transport of cellular cargoes. Dysregulation of DCTN2 has been linked to several diseases, particularly in cancer, where it has been shown to promote tumor progression. Elevated levels of DCTN2 expression are associated with poor prognosis in various malignancies, including hepatocellular carcinoma (HCC), where it enhances cell proliferation and metastasis by modulating key signaling pathways, such as the AKT pathway.