人 DAPP1 抗体对
01AB02472
Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1) is an adaptor protein characterized by its amino-terminal Src homology 2 (SH2) domain and carboxy-terminal pleckstrin homology (PH) domain, allowing it to bind with high affinity to tyrosine-phosphorylated proteins and specific phosphoinositides like PtdIns(3,4,5)P3 and PtdIns(3,4)P2. Expressed widely in cells, DAPP1 regulates signaling pathways by linking tyrosine kinase signaling and phosphoinositide metabolism, thereby modulating cellular responses to extracellular stimuli. It is especially involved in B-cell receptor (BCR) signaling downstream of phosphoinositide 3-kinase (PI3K), influencing immune cell activation and function. Dysregulation or aberrant expression of DAPP1 has been implicated in immune system disorders, including potential roles in autoimmunity and lymphoma due to its critical role in B-cell signaling. Thus, DAPP1 is essential for normal immune function, and its malfunction can contribute to disease states involving immune dysregulation.
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技术参数
- 靶点基因名
- DAPP1
- 基因别名
- BAM32
- 蛋白别名
- dual adaptor of phosphotyrosine and 3-phosphoinositides 1; DAPP1
- UniProt
- Q9UN19
- 物种
- Human
产品详情
- 靶点名称
- DAPP1
- 蛋白名称
- dual adaptor of phosphotyrosine and 3-phosphoinositides 1
- 蛋白别名
- Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; hDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa
- 靶点基因名
- DAPP1
- 基因别名
- BAM32
- UniProt
- Q9UN19
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1) is an adaptor protein characterized by its amino-terminal Src homology 2 (SH2) domain and carboxy-terminal pleckstrin homology (PH) domain, allowing it to bind with high affinity to tyrosine-phosphorylated proteins and specific phosphoinositides like PtdIns(3,4,5)P3 and PtdIns(3,4)P2. Expressed widely in cells, DAPP1 regulates signaling pathways by linking tyrosine kinase signaling and phosphoinositide metabolism, thereby modulating cellular responses to extracellular stimuli. It is especially involved in B-cell receptor (BCR) signaling downstream of phosphoinositide 3-kinase (PI3K), influencing immune cell activation and function. Dysregulation or aberrant expression of DAPP1 has been implicated in immune system disorders, including potential roles in autoimmunity and lymphoma due to its critical role in B-cell signaling. Thus, DAPP1 is essential for normal immune function, and its malfunction can contribute to disease states involving immune dysregulation.