人 DAB2 抗体对
01AB03104
DAB adaptor protein 2 (DAB2), also known as Disabled-2, is a cytosolic clathrin-associated sorting protein (CLASP) essential for clathrin-mediated endocytosis. It utilizes an N-terminal PTB domain to bind cargo, including the LDL receptor and integrins, linking them to the endocytic machinery via interactions with AP-2 and myosin VI. Beyond trafficking, DAB2 modulates signaling pathways such as TGF-beta and Wnt, and regulates platelet integrin function. Frequently downregulated in epithelial cancers, DAB2 functions as a putative tumor suppressor, maintaining cell polarity and inhibiting unconstrained growth.
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技术参数
- 靶点基因名
- DAB2
- 基因别名
- DOC2
- 蛋白别名
- DAB adaptor protein 2; DAB2
- UniProt
- P98082
- 物种
- Human
产品详情
- 靶点名称
- DAB2
- 蛋白名称
- DAB adaptor protein 2
- 蛋白别名
- Disabled homolog 2; Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Differentially-expressed protein 2
- 靶点基因名
- DAB2
- 基因别名
- DOC2
- UniProt
- P98082
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DAB adaptor protein 2 (DAB2), also known as Disabled-2, is a cytosolic clathrin-associated sorting protein (CLASP) essential for clathrin-mediated endocytosis. It utilizes an N-terminal PTB domain to bind cargo, including the LDL receptor and integrins, linking them to the endocytic machinery via interactions with AP-2 and myosin VI. Beyond trafficking, DAB2 modulates signaling pathways such as TGF-beta and Wnt, and regulates platelet integrin function. Frequently downregulated in epithelial cancers, DAB2 functions as a putative tumor suppressor, maintaining cell polarity and inhibiting unconstrained growth.