人 CZIB 抗体对
01AB01948
CXXC motif containing zinc binding protein (CZIB) is a small, evolutionarily conserved intracellular protein characterized by two canonical Cys-X-X-Cys (CXXC) motifs. These motifs facilitate the tetrahedral coordination of a zinc ion via four cysteine thiolates, which is essential for the protein's structural integrity and function. CZIB specifically interacts with the heavy-metal-associated (HMA) domain of the copper chaperone for superoxide dismutase (CCS). This interaction requires intact CXXC motifs in both partners, suggesting that CZIB plays a specialized role in metal-mediated protein-protein interactions and intracellular metal handling. As a soluble protein lacking transmembrane domains, CZIB is primarily involved in zinc and protein binding within the cytosol. Its conserved nature across species underscores its importance in maintaining metal homeostasis and supporting the functional assembly of metal-dependent chaperone complexes.
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技术参数
- 靶点基因名
- CZIB
- 基因别名
- C1orf123
- 蛋白别名
- CXXC motif containing zinc binding protein; CZIB
- UniProt
- Q9NWV4
- 物种
- Human
产品详情
- 靶点名称
- CZIB
- 蛋白名称
- CXXC motif containing zinc binding protein
- 蛋白别名
- CXXC motif containing zinc binding protein; UPF0587 protein C1orf123
- 靶点基因名
- CZIB
- 基因别名
- C1orf123
- UniProt
- Q9NWV4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CXXC motif containing zinc binding protein (CZIB) is a small, evolutionarily conserved intracellular protein characterized by two canonical Cys-X-X-Cys (CXXC) motifs. These motifs facilitate the tetrahedral coordination of a zinc ion via four cysteine thiolates, which is essential for the protein's structural integrity and function. CZIB specifically interacts with the heavy-metal-associated (HMA) domain of the copper chaperone for superoxide dismutase (CCS). This interaction requires intact CXXC motifs in both partners, suggesting that CZIB plays a specialized role in metal-mediated protein-protein interactions and intracellular metal handling. As a soluble protein lacking transmembrane domains, CZIB is primarily involved in zinc and protein binding within the cytosol. Its conserved nature across species underscores its importance in maintaining metal homeostasis and supporting the functional assembly of metal-dependent chaperone complexes.