人 CYTIP 抗体对
01AB01097
Cytohesin 1 interacting protein (CYTIP) is a cytoplasmic protein encoded by the CYTIP gene in humans and is characterized by two leucine zipper domains and a putative C-terminal nuclear targeting signal, lacking hydrophobic regions. CYTIP binds to cytohesin-1 (CYTH1), modulating the activation of ADP-ribosylation factors (ARFs) by sequestering CYTH1 in the cytoplasm, thereby influencing intracellular signaling pathways. It is weakly expressed in resting natural killer (NK) and T cells but is upregulated during dendritic cell (DC) maturation and T cell activation, playing a key role in immune regulation. Functionally, CYTIP regulates lymphocyte adhesion, cell-cell interactions, and signaling cascades, particularly affecting DC-mediated immune responses. Deficiency in CYTIP leads to heightened inflammatory reactions, as observed in contact hypersensitivity models, with increased IL-12 production and enhanced immune activation, suggesting its involvement in controlling immune-mediated inflammatory diseases.
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技术参数
- 靶点基因名
- CYTIP
- 基因别名
- PSCDBP
- 蛋白别名
- cytohesin 1 interacting protein; CYTIP
- UniProt
- O60759
- 物种
- Human
产品详情
- 靶点名称
- CYTIP
- 蛋白名称
- cytohesin 1 interacting protein
- 蛋白别名
- Cytohesin-interacting protein; Cytohesin binder and regulator; CYBR; Cytohesin-associated scaffolding protein; CASP; Cytohesin-binding protein HE; Cbp HE; Pleckstrin homology Sec7 and coiled-coil domains-binding protein
- 靶点基因名
- CYTIP
- 基因别名
- PSCDBP
- UniProt
- O60759
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cytohesin 1 interacting protein (CYTIP) is a cytoplasmic protein encoded by the CYTIP gene in humans and is characterized by two leucine zipper domains and a putative C-terminal nuclear targeting signal, lacking hydrophobic regions. CYTIP binds to cytohesin-1 (CYTH1), modulating the activation of ADP-ribosylation factors (ARFs) by sequestering CYTH1 in the cytoplasm, thereby influencing intracellular signaling pathways. It is weakly expressed in resting natural killer (NK) and T cells but is upregulated during dendritic cell (DC) maturation and T cell activation, playing a key role in immune regulation. Functionally, CYTIP regulates lymphocyte adhesion, cell-cell interactions, and signaling cascades, particularly affecting DC-mediated immune responses. Deficiency in CYTIP leads to heightened inflammatory reactions, as observed in contact hypersensitivity models, with increased IL-12 production and enhanced immune activation, suggesting its involvement in controlling immune-mediated inflammatory diseases.