抗人 Cyclophilin-40 抗体对
01AB02014
Peptidylprolyl isomerase D (Cyclophilin-40) is a cytosolic immunophilin and a member of the peptidyl-prolyl cis-trans isomerase family. It functions as a foldase chaperone by catalyzing the cis-trans isomerization of proline imidic peptide bonds, thereby facilitating proper protein folding and conformational repair. The protein features a canonical cyclophilin β-barrel domain for its isomerase activity and a C-terminal tetratricopeptide repeat domain that mediates essential interactions with Hsp90 and other client complexes. By integrating into multi-protein chaperone assemblies and binding cyclosporin A, Peptidylprolyl isomerase D plays a central role in modulating protein homeostasis and immunosuppressive signaling pathways within the cell.
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技术参数
- 靶点基因名
- PPID
- 基因别名
- CYP40; CYPD
- 蛋白别名
- peptidylprolyl isomerase D; Cyclophilin-40
- UniProt
- Q08752
- 物种
- Human
产品详情
- 靶点名称
- Cyclophilin-40
- 蛋白名称
- peptidylprolyl isomerase D
- 蛋白别名
- Peptidyl-prolyl cis-trans isomerase D; PPIase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D
- 靶点基因名
- PPID
- 基因别名
- CYP40; CYPD
- UniProt
- Q08752
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Peptidylprolyl isomerase D (Cyclophilin-40) is a cytosolic immunophilin and a member of the peptidyl-prolyl cis-trans isomerase family. It functions as a foldase chaperone by catalyzing the cis-trans isomerization of proline imidic peptide bonds, thereby facilitating proper protein folding and conformational repair. The protein features a canonical cyclophilin β-barrel domain for its isomerase activity and a C-terminal tetratricopeptide repeat domain that mediates essential interactions with Hsp90 and other client complexes. By integrating into multi-protein chaperone assemblies and binding cyclosporin A, Peptidylprolyl isomerase D plays a central role in modulating protein homeostasis and immunosuppressive signaling pathways within the cell.