人 CXCL2 抗体对
01AB03100
C-X-C motif chemokine ligand 2 (CXCL2) is a secreted ELR+ CXC chemokine, also known as GRO-beta or MIP-2-alpha, primarily produced by activated monocytes, macrophages, and various stromal cells. It functions as a potent chemoattractant for neutrophils and other polymorphonuclear leukocytes by binding to the G protein-coupled receptor CXCR2. This interaction triggers downstream signaling pathways that induce cytoskeletal remodeling, cell migration, and adhesion. CXCL2 plays a critical role in orchestrating leukocyte recruitment during acute inflammation and contributes to wound healing and antimicrobial defense. Pathologically, dysregulated CXCL2-CXCR2 signaling is implicated in obesity-associated adipose tissue inflammation, stroke-related brain infiltration, and various chronic inflammatory diseases. In oncology, it promotes tumor proliferation, angiogenesis, and metastasis.
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技术参数
- 靶点基因名
- CXCL2
- 基因别名
- GRO2; GROB; MIP2A; SCYB2
- 蛋白别名
- C-X-C motif chemokine ligand 2; CXCL2
- UniProt
- P19875
- 物种
- Human
产品详情
- 靶点名称
- CXCL2
- 蛋白名称
- C-X-C motif chemokine ligand 2
- 蛋白别名
- C-X-C motif chemokine 2; Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha) [Cleaved into: GRO-beta(5-73; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353]
- 靶点基因名
- CXCL2
- 基因别名
- GRO2; GROB; MIP2A; SCYB2
- UniProt
- P19875
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
C-X-C motif chemokine ligand 2 (CXCL2) is a secreted ELR+ CXC chemokine, also known as GRO-beta or MIP-2-alpha, primarily produced by activated monocytes, macrophages, and various stromal cells. It functions as a potent chemoattractant for neutrophils and other polymorphonuclear leukocytes by binding to the G protein-coupled receptor CXCR2. This interaction triggers downstream signaling pathways that induce cytoskeletal remodeling, cell migration, and adhesion. CXCL2 plays a critical role in orchestrating leukocyte recruitment during acute inflammation and contributes to wound healing and antimicrobial defense. Pathologically, dysregulated CXCL2-CXCR2 signaling is implicated in obesity-associated adipose tissue inflammation, stroke-related brain infiltration, and various chronic inflammatory diseases. In oncology, it promotes tumor proliferation, angiogenesis, and metastasis.