人 CUL5 抗体对
01AB01462
Cullin-5 (CUL5) is a scaffold protein that forms the core of the cullin-RING ubiquitin ligase complex CRL5. CUL5 binds to adaptor proteins like Elongin B/C and substrate receptor proteins like SOCS at its N-terminus, and to the RING protein RBX2 at its C-terminus. This allows CRL5 to recruit specific substrates for ubiquitination and subsequent proteasomal degradation. CUL5 plays important roles in regulating cell growth, proliferation, and other physiological processes. Additionally, CUL5 is involved in the cellular response to DNA damage and inhibition of cell migration. Downregulation of CUL5 has been observed in various cancers, suggesting a potential tumor suppressor function. CUL5 has been implicated in the ubiquitination of oncoproteins like HIF-1α and tumor suppressors like p53, highlighting its complex role in cancer pathogenesis.
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技术参数
- 靶点基因名
- CUL5
- 基因别名
- VACM1
- 蛋白别名
- cullin 5; CUL5
- UniProt
- Q93034
- 物种
- Human
产品详情
- 靶点名称
- CUL5
- 蛋白名称
- cullin 5
- 蛋白别名
- Cullin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1
- 靶点基因名
- CUL5
- 基因别名
- VACM1
- UniProt
- Q93034
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cullin-5 (CUL5) is a scaffold protein that forms the core of the cullin-RING ubiquitin ligase complex CRL5. CUL5 binds to adaptor proteins like Elongin B/C and substrate receptor proteins like SOCS at its N-terminus, and to the RING protein RBX2 at its C-terminus. This allows CRL5 to recruit specific substrates for ubiquitination and subsequent proteasomal degradation. CUL5 plays important roles in regulating cell growth, proliferation, and other physiological processes. Additionally, CUL5 is involved in the cellular response to DNA damage and inhibition of cell migration. Downregulation of CUL5 has been observed in various cancers, suggesting a potential tumor suppressor function. CUL5 has been implicated in the ubiquitination of oncoproteins like HIF-1α and tumor suppressors like p53, highlighting its complex role in cancer pathogenesis.