人 CTSV 抗体对
01AB01091
Cathepsin V (CTSV), also known as cathepsin L2 or cathepsin U, is a lysosomal cysteine protease belonging to the papain-like protease family (MEROPS family C1) and exhibits endopeptidase activity, primarily functioning in protein degradation within lysosomes. CTSV is notable for its non-canonical localization to the nucleus, where it regulates cell cycle progression and histone stability by modulating the levels of histones H3 and H4 and their chaperone sNASP, highlighting its roles beyond traditional proteolysis. The protein is expressed in various tissues and is upregulated in certain cancers, such as colorectal and breast carcinomas, but not in corresponding normal tissues, suggesting a role in tumorigenesis. Clinically, CTSV has been implicated in the progression of bladder cancer via activation of the NF-κB pathway and may contribute to the pathogenesis of keratoconus.
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技术参数
- 靶点基因名
- CTSV
- 基因别名
- CATL2; CTSL2; CTSU
- 蛋白别名
- cathepsin V; CTSV
- UniProt
- O60911
- 物种
- Human
产品详情
- 靶点名称
- CTSV
- 蛋白名称
- cathepsin V
- 蛋白别名
- Cathepsin L2; Cathepsin U; Cathepsin V
- 靶点基因名
- CTSV
- 基因别名
- CATL2; CTSL2; CTSU
- UniProt
- O60911
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cathepsin V (CTSV), also known as cathepsin L2 or cathepsin U, is a lysosomal cysteine protease belonging to the papain-like protease family (MEROPS family C1) and exhibits endopeptidase activity, primarily functioning in protein degradation within lysosomes. CTSV is notable for its non-canonical localization to the nucleus, where it regulates cell cycle progression and histone stability by modulating the levels of histones H3 and H4 and their chaperone sNASP, highlighting its roles beyond traditional proteolysis. The protein is expressed in various tissues and is upregulated in certain cancers, such as colorectal and breast carcinomas, but not in corresponding normal tissues, suggesting a role in tumorigenesis. Clinically, CTSV has been implicated in the progression of bladder cancer via activation of the NF-κB pathway and may contribute to the pathogenesis of keratoconus.