人 CTSL 抗体对
01AB01086
Cathepsin L (CTSL) is a lysosomal cysteine protease belonging to the papain-like family, widely expressed in eukaryotic cells and primarily involved in intracellular protein catabolism, including the degradation of collagen, elastin, and other proteins essential for cellular turnover and growth regulation. It plays a critical role in processes such as antigen processing, cell cycle progression, apoptosis, and the turnover of both intracellular and secreted proteins. Cathepsin L is also secreted in its pro-form and is a major excreted protein in certain malignantly transformed cells, contributing to tumor invasion, metastasis, and bone resorption. Beyond its physiological functions, CTSL is implicated in pathological conditions, including facilitating viral entry (notably SARS-CoV-2), promoting tissue inflammation when secreted by immune cells, and contributing to diseases such as myopathies, myocardial ischemia, and cancer progression.
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技术参数
- 靶点基因名
- CTSL
- 基因别名
- CTSL1
- 蛋白别名
- cathepsin L; CTSL
- UniProt
- P07711
- 物种
- Human
产品详情
- 靶点名称
- CTSL
- 蛋白名称
- cathepsin L
- 蛋白别名
- Procathepsin L; Cathepsin L1; Major excreted protein; MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
- 靶点基因名
- CTSL
- 基因别名
- CTSL1
- UniProt
- P07711
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cathepsin L (CTSL) is a lysosomal cysteine protease belonging to the papain-like family, widely expressed in eukaryotic cells and primarily involved in intracellular protein catabolism, including the degradation of collagen, elastin, and other proteins essential for cellular turnover and growth regulation. It plays a critical role in processes such as antigen processing, cell cycle progression, apoptosis, and the turnover of both intracellular and secreted proteins. Cathepsin L is also secreted in its pro-form and is a major excreted protein in certain malignantly transformed cells, contributing to tumor invasion, metastasis, and bone resorption. Beyond its physiological functions, CTSL is implicated in pathological conditions, including facilitating viral entry (notably SARS-CoV-2), promoting tissue inflammation when secreted by immune cells, and contributing to diseases such as myopathies, myocardial ischemia, and cancer progression.