人 CTSF 抗体对
01AB00200
Cathepsin F (CTSF) is a lysosomal cysteine protease belonging to the papain family, playing a crucial role in the lysosomal proteolytic system. It is encoded by the CTSF gene, which maps to chromosome 11q13 and is ubiquitously expressed. The protein contains a 19-residue signal peptide and a unique proregion with a cystatin-like domain, which is predicted to have inhibitory activity. CTSF mutations have been identified as a cause of Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis characterized by dementia and motor features. CTSF is also involved in processing the invariant chain associated with the major histocompatibility complex (MHC) class II, suggesting its role in immune regulation.
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技术参数
- 靶点基因名
- CTSF
- 蛋白别名
- cathepsin F; CTSF
- UniProt
- Q9UBX1
- 物种
- Human
产品详情
- 靶点名称
- CTSF
- 蛋白名称
- cathepsin F
- 蛋白别名
- Cathepsin F; CATSF
- 靶点基因名
- CTSF
- UniProt
- Q9UBX1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cathepsin F (CTSF) is a lysosomal cysteine protease belonging to the papain family, playing a crucial role in the lysosomal proteolytic system. It is encoded by the CTSF gene, which maps to chromosome 11q13 and is ubiquitously expressed. The protein contains a 19-residue signal peptide and a unique proregion with a cystatin-like domain, which is predicted to have inhibitory activity. CTSF mutations have been identified as a cause of Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis characterized by dementia and motor features. CTSF is also involved in processing the invariant chain associated with the major histocompatibility complex (MHC) class II, suggesting its role in immune regulation.