人 CTRC 抗体对
01AB02588
CTRC (Chymotrypsin C) is an enzyme that plays a crucial role in pancreatic protection and the pathogenesis of chronic pancreatitis. It degrades all human trypsin and trypsinogen isoforms with high specificity, mitigating premature trypsinogen activation in the pancreas. Mutations in the CTRC gene can lead to diminished CTRC activity or secretion, predisposing individuals to chronic pancreatitis. Several missense and deletion variants in CTRC have been identified in patients with idiopathic or hereditary pancreatitis, with some variants showing impaired secretion or activity in functional studies. Loss-of-function alterations in CTRC are associated with an increased risk of chronic pancreatitis, likely due to diminished protective trypsin degradation.CTRC plays a protective role in the pancreas by regulating trypsinogen activation, and its dysfunction contributes to the pathogenesis of chronic pancreatitis.
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技术参数
- 靶点基因名
- CTRC
- 基因别名
- CLCR
- 蛋白别名
- chymotrypsin C; CTRC
- UniProt
- Q99895
- 物种
- Human
产品详情
- 靶点名称
- CTRC
- 蛋白名称
- chymotrypsin C
- 蛋白别名
- Chymotrypsin-C; Caldecrin
- 靶点基因名
- CTRC
- 基因别名
- CLCR
- UniProt
- Q99895
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CTRC (Chymotrypsin C) is an enzyme that plays a crucial role in pancreatic protection and the pathogenesis of chronic pancreatitis. It degrades all human trypsin and trypsinogen isoforms with high specificity, mitigating premature trypsinogen activation in the pancreas. Mutations in the CTRC gene can lead to diminished CTRC activity or secretion, predisposing individuals to chronic pancreatitis. Several missense and deletion variants in CTRC have been identified in patients with idiopathic or hereditary pancreatitis, with some variants showing impaired secretion or activity in functional studies. Loss-of-function alterations in CTRC are associated with an increased risk of chronic pancreatitis, likely due to diminished protective trypsin degradation.CTRC plays a protective role in the pancreas by regulating trypsinogen activation, and its dysfunction contributes to the pathogenesis of chronic pancreatitis.