抗人 CTRB1 抗体对
01AB02815
Chymotrypsinogen B1 (CTRB1) is a pancreatic zymogen and the primary precursor of the digestive serine protease chymotrypsin B. Secreted into the duodenum, it is activated to cleave peptide bonds C-terminal to hydrophobic or aromatic residues, playing a central role in dietary protein digestion. CTRB1 exhibits isoform-specific substrate specificity distinct from its paralog CTRB2, influencing the regulation of intrapancreatic trypsin activity. Genetic variations in the CTRB1 locus, particularly structural inversions that alter isoform expression balance, are significantly associated with susceptibility to chronic pancreatitis and have been linked to pancreatic acinar cell adenocarcinoma.
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技术参数
- 靶点基因名
- CTRB1
- 基因别名
- CTRB
- 蛋白别名
- chymotrypsinogen B1; CTRB1
- UniProt
- P17538
- 物种
- Human
产品详情
- 靶点名称
- CTRB1
- 蛋白名称
- chymotrypsinogen B1
- 蛋白别名
- Chymotrypsinogen B [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
- 靶点基因名
- CTRB1
- 基因别名
- CTRB
- UniProt
- P17538
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Chymotrypsinogen B1 (CTRB1) is a pancreatic zymogen and the primary precursor of the digestive serine protease chymotrypsin B. Secreted into the duodenum, it is activated to cleave peptide bonds C-terminal to hydrophobic or aromatic residues, playing a central role in dietary protein digestion. CTRB1 exhibits isoform-specific substrate specificity distinct from its paralog CTRB2, influencing the regulation of intrapancreatic trypsin activity. Genetic variations in the CTRB1 locus, particularly structural inversions that alter isoform expression balance, are significantly associated with susceptibility to chronic pancreatitis and have been linked to pancreatic acinar cell adenocarcinoma.