人 CTNNBIP1 抗体对
01AB03098
Catenin beta interacting protein 1 (CTNNBIP1) is a small cytosolic protein that acts as a potent negative regulator of the Wnt/beta-catenin signaling pathway. It functions by binding to beta-catenin and physically blocking its interaction with TCF family transcription factors, thereby preventing the activation of Wnt target genes involved in cell proliferation and differentiation. By serving as a molecular brake on the Wnt pathway, CTNNBIP1 maintains cellular homeostasis and prevents aberrant signaling. Clinically, the downregulation or loss of CTNNBIP1 is associated with the progression of various diseases, including hepatocellular carcinoma and inflammatory skin conditions such as psoriasis, where its absence leads to increased keratinocyte proliferation.
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技术参数
- 靶点基因名
- CTNNBIP1
- 基因别名
- ICAT
- 蛋白别名
- catenin beta interacting protein 1; CTNNBIP1
- UniProt
- Q9NSA3
- 物种
- Human
产品详情
- 靶点名称
- CTNNBIP1
- 蛋白名称
- catenin beta interacting protein 1
- 蛋白别名
- Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4
- 靶点基因名
- CTNNBIP1
- 基因别名
- ICAT
- UniProt
- Q9NSA3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Catenin beta interacting protein 1 (CTNNBIP1) is a small cytosolic protein that acts as a potent negative regulator of the Wnt/beta-catenin signaling pathway. It functions by binding to beta-catenin and physically blocking its interaction with TCF family transcription factors, thereby preventing the activation of Wnt target genes involved in cell proliferation and differentiation. By serving as a molecular brake on the Wnt pathway, CTNNBIP1 maintains cellular homeostasis and prevents aberrant signaling. Clinically, the downregulation or loss of CTNNBIP1 is associated with the progression of various diseases, including hepatocellular carcinoma and inflammatory skin conditions such as psoriasis, where its absence leads to increased keratinocyte proliferation.