人 CTLA4 抗体对
01AB00155
CTLA-4 (Cytotoxic T-Lymphocyte Antigen-4) is a crucial negative regulator of T-cell activation and plays a pivotal role in maintaining immune homeostasis and self-tolerance. Dysregulation or deficiency of CTLA-4 leads to uncontrolled T-cell activation and proliferation, resulting in a breakdown of self-tolerance and susceptibility to various autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, and myasthenia gravis. Conversely, polymorphisms or mutations in the CTLA-4 gene have been associated with an increased risk of autoimmune disorders. CTLA-4 plays a crucial role in regulating anti-tumor immunity, and its blockade through checkpoint inhibitors like ipilimumab has shown promising results in cancer immunotherapy.
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技术参数
- 靶点基因名
- CTLA4
- 基因别名
- CD152
- 蛋白别名
- cytotoxic T-lymphocyte associated protein 4; CTLA4
- UniProt
- P16410
- 物种
- Human
产品详情
- 靶点名称
- CTLA4
- 蛋白名称
- cytotoxic T-lymphocyte associated protein 4
- 蛋白别名
- Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD antigen CD152
- 靶点基因名
- CTLA4
- 基因别名
- CD152
- UniProt
- P16410
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CTLA-4 (Cytotoxic T-Lymphocyte Antigen-4) is a crucial negative regulator of T-cell activation and plays a pivotal role in maintaining immune homeostasis and self-tolerance. Dysregulation or deficiency of CTLA-4 leads to uncontrolled T-cell activation and proliferation, resulting in a breakdown of self-tolerance and susceptibility to various autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, and myasthenia gravis. Conversely, polymorphisms or mutations in the CTLA-4 gene have been associated with an increased risk of autoimmune disorders. CTLA-4 plays a crucial role in regulating anti-tumor immunity, and its blockade through checkpoint inhibitors like ipilimumab has shown promising results in cancer immunotherapy.