人 CTDSPL2 抗体对
01AB03221
CTD small phosphatase like 2 (CTDSPL2) is a nuclear phosphatase that dephosphorylates the C-terminal domain of RNA polymerase II, thereby regulating transcription and protein export. Beyond its physiological roles in BMP signaling and transcriptional control, CTDSPL2 functions as a context-dependent oncogene. It stabilizes Snail to promote epithelial-to-mesenchymal transition and activates the PI3K/AKT pathway via JAK1, driving proliferation, invasion, and metastasis in non-small cell lung cancer. In leukemic cells, it supports growth through the dephosphorylation of specific kinases. Consequently, CTDSPL2 represents a potential therapeutic target in malignancies where it is overexpressed.
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技术参数
- 靶点基因名
- CTDSPL2
- 蛋白别名
- CTD small phosphatase like 2; CTDSPL2
- UniProt
- Q05D32
- 物种
- Human
产品详情
- 靶点名称
- CTDSPL2
- 蛋白名称
- CTD small phosphatase like 2
- 蛋白别名
- CTD small phosphatase-like protein 2; CTDSP-like 2
- 靶点基因名
- CTDSPL2
- UniProt
- Q05D32
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CTD small phosphatase like 2 (CTDSPL2) is a nuclear phosphatase that dephosphorylates the C-terminal domain of RNA polymerase II, thereby regulating transcription and protein export. Beyond its physiological roles in BMP signaling and transcriptional control, CTDSPL2 functions as a context-dependent oncogene. It stabilizes Snail to promote epithelial-to-mesenchymal transition and activates the PI3K/AKT pathway via JAK1, driving proliferation, invasion, and metastasis in non-small cell lung cancer. In leukemic cells, it supports growth through the dephosphorylation of specific kinases. Consequently, CTDSPL2 represents a potential therapeutic target in malignancies where it is overexpressed.