抗人 CTAG2 抗体对
01AB02810
Cancer/testis antigen 2 (CTAG2) is an X-linked tumor antigen of the ESO/LAGE family, normally restricted to testis tissue but aberrantly expressed in various malignancies, including melanoma, breast, and prostate cancers. The protein localizes diffusely in the cytoplasm with a distinct accumulation at the centrosome, where it interacts with the scaffolding protein Pericentrin to regulate centrosomal function and cell cycle dynamics. Functionally, CTAG2 promotes the directional migration and collective invasion of cancer cells, contributing to metastatic behavior. Due to its limited expression in somatic tissues and prevalence in tumors, CTAG2 is investigated as a target for cancer immunotherapy.
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技术参数
- 靶点基因名
- CTAG2
- 基因别名
- ESO2; LAGE1
- 蛋白别名
- cancer/testis antigen 2; CTAG2
- UniProt
- O75638
- 物种
- Human
产品详情
- 靶点名称
- CTAG2
- 蛋白名称
- cancer/testis antigen 2
- 蛋白别名
- Cancer/testis antigen 2; CT2; Autoimmunogenic cancer/testis antigen NY-ESO-2; Cancer/testis antigen 6.2; CT6.2; L antigen family member 1; LAGE-1
- 靶点基因名
- CTAG2
- 基因别名
- ESO2; LAGE1
- UniProt
- O75638
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cancer/testis antigen 2 (CTAG2) is an X-linked tumor antigen of the ESO/LAGE family, normally restricted to testis tissue but aberrantly expressed in various malignancies, including melanoma, breast, and prostate cancers. The protein localizes diffusely in the cytoplasm with a distinct accumulation at the centrosome, where it interacts with the scaffolding protein Pericentrin to regulate centrosomal function and cell cycle dynamics. Functionally, CTAG2 promotes the directional migration and collective invasion of cancer cells, contributing to metastatic behavior. Due to its limited expression in somatic tissues and prevalence in tumors, CTAG2 is investigated as a target for cancer immunotherapy.