人 CST6 抗体对
01AB03996
Cystatin E/M (CST6) is a cysteine protease inhibitor belonging to the type 2 cystatin family, known for its role in regulating proteolytic activity in various human fluids and tissues. It is encoded by the CST6 gene located on chromosome 11 and is synthesized as a secretory protein with a signal peptide for secretion. CST6 exhibits high affinity for cathepsin L and legumain, playing crucial roles in epidermal cornification and hair follicle maintenance. Loss of CST6 expression has been linked to several diseases, including ectodermal dysplasia and ichthyosis, highlighting its importance in skin and hair development. Furthermore, CST6 is implicated in suppressing osteolytic bone disease in multiple myeloma by inhibiting osteoclast differentiation, underscoring its multifaceted role in disease progression and tissue homeostasis. Overall, CST6 is a significant protein with protective functions that may influence cancer metastasis and other pathological conditions.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CST6
- 蛋白别名
- cystatin E/M; CST6
- UniProt
- Q15828
- 物种
- Human
产品详情
- 靶点名称
- CST6
- 蛋白名称
- cystatin E/M
- 蛋白别名
- Cystatin-M; Cystatin-6; Cystatin-E
- 靶点基因名
- CST6
- UniProt
- Q15828
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cystatin E/M (CST6) is a cysteine protease inhibitor belonging to the type 2 cystatin family, known for its role in regulating proteolytic activity in various human fluids and tissues. It is encoded by the CST6 gene located on chromosome 11 and is synthesized as a secretory protein with a signal peptide for secretion. CST6 exhibits high affinity for cathepsin L and legumain, playing crucial roles in epidermal cornification and hair follicle maintenance. Loss of CST6 expression has been linked to several diseases, including ectodermal dysplasia and ichthyosis, highlighting its importance in skin and hair development. Furthermore, CST6 is implicated in suppressing osteolytic bone disease in multiple myeloma by inhibiting osteoclast differentiation, underscoring its multifaceted role in disease progression and tissue homeostasis. Overall, CST6 is a significant protein with protective functions that may influence cancer metastasis and other pathological conditions.