抗人 CSDE1 抗体对
01AB02403
Cold shock domain containing E1 (CSDE1) is a cytoplasmic RNA-binding protein that regulates the translation and stability of target mRNAs. It contains multiple cold shock domains that recognize purine-rich single-stranded RNA motifs, often binding near start and stop codons. CSDE1 acts as an IRES trans-acting factor (ITAF), modulating the cap-independent translation of key proteins such as c-MYC and APAF1. It also participates in stress granule formation and miRNA biogenesis, serving as a molecular adaptor for various ribonucleoprotein complexes. In oncology, CSDE1 has emerged as a critical post-transcriptional regulator that coordinates mRNA regulons involved in proliferation, survival, and invasion. Depending on the cellular context and its binding partners, CSDE1 can exert either oncogenic or tumor-suppressive effects.
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技术参数
- 靶点基因名
- CSDE1
- 基因别名
- D1S155E; KIAA0885; NRU; UNR
- 蛋白别名
- cold shock domain containing E1; CSDE1
- UniProt
- O75534
- 物种
- Human
产品详情
- 靶点名称
- CSDE1
- 蛋白名称
- cold shock domain containing E1
- 蛋白别名
- Cold shock domain-containing protein E1; N-ras upstream gene protein; Protein UNR
- 靶点基因名
- CSDE1
- 基因别名
- D1S155E; KIAA0885; NRU; UNR
- UniProt
- O75534
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cold shock domain containing E1 (CSDE1) is a cytoplasmic RNA-binding protein that regulates the translation and stability of target mRNAs. It contains multiple cold shock domains that recognize purine-rich single-stranded RNA motifs, often binding near start and stop codons. CSDE1 acts as an IRES trans-acting factor (ITAF), modulating the cap-independent translation of key proteins such as c-MYC and APAF1. It also participates in stress granule formation and miRNA biogenesis, serving as a molecular adaptor for various ribonucleoprotein complexes. In oncology, CSDE1 has emerged as a critical post-transcriptional regulator that coordinates mRNA regulons involved in proliferation, survival, and invasion. Depending on the cellular context and its binding partners, CSDE1 can exert either oncogenic or tumor-suppressive effects.