人 CRNN 抗体对
01AB01081
Cornulin (CRNN) is a 495-amino acid, squamous epithelial tissue-specific protein encoded by the CRNN gene located at chromosome 1q21.3, within the epidermal differentiation complex region. Structurally, Cornulin belongs to the "fused gene" family and contains two EF-hand calcium-binding domains at its N-terminus and two glutamine- and threonine-rich 60-amino acid repeats at its C-terminus, features that are important for its role in calcium signaling and epidermal differentiation. Cornulin is involved in the mucosal and epithelial immune response, acts as a survival factor for squamous epithelial cells, and helps regulate cell proliferation by inducing G1 cell cycle arrest. Disease associations include its downregulation in eczema and upregulation in psoriasis, as well as links to esophageal cancer and squamous cell carcinoma, where altered Cornulin expression correlates with enhanced metastasis and poorer survival outcomes.
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技术参数
- 靶点基因名
- CRNN
- 基因别名
- C1orf10; DRC1; PDRC1; SEP53
- 蛋白别名
- cornulin; CRNN
- UniProt
- Q9UBG3
- 物种
- Human
产品详情
- 靶点名称
- CRNN
- 蛋白名称
- cornulin
- 蛋白别名
- Cornulin; 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein
- 靶点基因名
- CRNN
- 基因别名
- C1orf10; DRC1; PDRC1; SEP53
- UniProt
- Q9UBG3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cornulin (CRNN) is a 495-amino acid, squamous epithelial tissue-specific protein encoded by the CRNN gene located at chromosome 1q21.3, within the epidermal differentiation complex region. Structurally, Cornulin belongs to the "fused gene" family and contains two EF-hand calcium-binding domains at its N-terminus and two glutamine- and threonine-rich 60-amino acid repeats at its C-terminus, features that are important for its role in calcium signaling and epidermal differentiation. Cornulin is involved in the mucosal and epithelial immune response, acts as a survival factor for squamous epithelial cells, and helps regulate cell proliferation by inducing G1 cell cycle arrest. Disease associations include its downregulation in eczema and upregulation in psoriasis, as well as links to esophageal cancer and squamous cell carcinoma, where altered Cornulin expression correlates with enhanced metastasis and poorer survival outcomes.