抗人 CRLF3 抗体对
01AB02394
Cytokine receptor like factor 3 (CRLF3) is a conserved class I-like cytokine receptor that plays a role in cell cycle control, neuronal morphology, and synaptic vesicle biogenesis. It is a single-pass type I membrane protein containing a fibronectin type III domain and a C-terminal SPRY domain. CRLF3 has been identified as a receptor for erythropoietin (Epo) and its splice variant EV-3, mediating anti-apoptotic neuroprotection in human neurons. It also influences microtubule stability and RhoA/Hippo signaling pathways. Clinically, disruption of the CRLF3 gene or its surrounding region is associated with neurofibromatosis type 1 (NF1) microdeletion syndromes and various neurodevelopmental defects. Additionally, CRLF3 is linked to altered thrombopoiesis and has emerging roles as a context-dependent modifier in both hematologic and solid malignancies.
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技术参数
- 靶点基因名
- CRLF3
- 基因别名
- CREME9; CRLM9; CYTOR4; P48
- 蛋白别名
- cytokine receptor like factor 3; CRLF3
- UniProt
- Q8IUI8
- 物种
- Human
产品详情
- 靶点名称
- CRLF3
- 蛋白名称
- cytokine receptor like factor 3
- 蛋白别名
- Cytokine receptor-like factor 3; Cytokine receptor-like molecule 9; CREME-9; Cytokine receptor-related protein 4; Type I cytokine receptor-like factor p48
- 靶点基因名
- CRLF3
- 基因别名
- CREME9; CRLM9; CYTOR4; P48
- UniProt
- Q8IUI8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cytokine receptor like factor 3 (CRLF3) is a conserved class I-like cytokine receptor that plays a role in cell cycle control, neuronal morphology, and synaptic vesicle biogenesis. It is a single-pass type I membrane protein containing a fibronectin type III domain and a C-terminal SPRY domain. CRLF3 has been identified as a receptor for erythropoietin (Epo) and its splice variant EV-3, mediating anti-apoptotic neuroprotection in human neurons. It also influences microtubule stability and RhoA/Hippo signaling pathways. Clinically, disruption of the CRLF3 gene or its surrounding region is associated with neurofibromatosis type 1 (NF1) microdeletion syndromes and various neurodevelopmental defects. Additionally, CRLF3 is linked to altered thrombopoiesis and has emerging roles as a context-dependent modifier in both hematologic and solid malignancies.