人 CRISP2 抗体对
01AB00785
Cysteine rich secretory protein 2 (CRISP2) is a member of the CAP superfamily proteins predominantly expressed in the male reproductive tract during spermatogenesis, where it becomes incorporated into developing sperm head and tail. CRISP2 plays crucial roles in multiple aspects of sperm function, including regulating calcium fluxes during sperm capacitation by modulating ion channel activity, facilitating the acrosome reaction, and establishing normal flagellum waveform for proper sperm motility. The protein contains an N-terminal domain with cell-to-cell adhesion properties and a C-terminal domain that regulates calcium RyR channels, contributing to sperm hyperactivation. CRISP2 also participates in gamete fusion through interaction with egg plasma membrane complementary sites. Deficiency in CRISP2 results in subfertility in males due to impaired sperm motility, characterized by a stiff midpiece and inability to achieve rapid progressive movement. CRISP2 has been clinically associated with human fertility, as it binds to the CATSPER1 subunit of the Catsper ion channel necessary for normal sperm function.
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技术参数
- 靶点基因名
- CRISP2
- 基因别名
- GAPDL5; TPX1
- 蛋白别名
- cysteine rich secretory protein 2; CRISP2
- UniProt
- P16562
- 物种
- Human
产品详情
- 靶点名称
- CRISP2
- 蛋白名称
- cysteine rich secretory protein 2
- 蛋白别名
- Cysteine-rich secretory protein 2; CRISP-2; Cancer/testis antigen 36; CT36; Testis-specific protein TPX-1
- 靶点基因名
- CRISP2
- 基因别名
- GAPDL5; TPX1
- UniProt
- P16562
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cysteine rich secretory protein 2 (CRISP2) is a member of the CAP superfamily proteins predominantly expressed in the male reproductive tract during spermatogenesis, where it becomes incorporated into developing sperm head and tail. CRISP2 plays crucial roles in multiple aspects of sperm function, including regulating calcium fluxes during sperm capacitation by modulating ion channel activity, facilitating the acrosome reaction, and establishing normal flagellum waveform for proper sperm motility. The protein contains an N-terminal domain with cell-to-cell adhesion properties and a C-terminal domain that regulates calcium RyR channels, contributing to sperm hyperactivation. CRISP2 also participates in gamete fusion through interaction with egg plasma membrane complementary sites. Deficiency in CRISP2 results in subfertility in males due to impaired sperm motility, characterized by a stiff midpiece and inability to achieve rapid progressive movement. CRISP2 has been clinically associated with human fertility, as it binds to the CATSPER1 subunit of the Catsper ion channel necessary for normal sperm function.