人 CREG1 抗体对
01AB01671
Cellular repressor of E1A stimulated genes 1 (CREG1) is a secreted and lysosome-associated glycoprotein that modulates cell growth and differentiation. Structurally related to pyridoxine 5′-phosphate oxidase but lacking enzymatic activity, CREG1 undergoes proteolytic maturation in lysosomes and interacts with the mannose-6-phosphate/IGF2 receptor. It functions as a transcriptional repressor that antagonizes adenovirus E1A-mediated cellular transformation, thereby inhibiting proliferation and promoting senescence and differentiation. CREG1 is also critical for cardiovascular biology, where it facilitates cardiomyocyte differentiation and maintains myocardial structural integrity. Dysregulation of CREG1 is implicated in tumorigenesis due to its growth-suppressive properties and is relevant to cardiac development and potential regenerative therapies for heart pathology.
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技术参数
- 靶点基因名
- CREG1
- 基因别名
- CREG
- 蛋白别名
- cellular repressor of E1A stimulated genes 1; CREG1
- UniProt
- O75629
- 物种
- Human
产品详情
- 靶点名称
- CREG1
- 蛋白名称
- cellular repressor of E1A stimulated genes 1
- 蛋白别名
- Protein CREG1; Cellular repressor of E1A-stimulated genes 1
- 靶点基因名
- CREG1
- 基因别名
- CREG
- UniProt
- O75629
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cellular repressor of E1A stimulated genes 1 (CREG1) is a secreted and lysosome-associated glycoprotein that modulates cell growth and differentiation. Structurally related to pyridoxine 5′-phosphate oxidase but lacking enzymatic activity, CREG1 undergoes proteolytic maturation in lysosomes and interacts with the mannose-6-phosphate/IGF2 receptor. It functions as a transcriptional repressor that antagonizes adenovirus E1A-mediated cellular transformation, thereby inhibiting proliferation and promoting senescence and differentiation. CREG1 is also critical for cardiovascular biology, where it facilitates cardiomyocyte differentiation and maintains myocardial structural integrity. Dysregulation of CREG1 is implicated in tumorigenesis due to its growth-suppressive properties and is relevant to cardiac development and potential regenerative therapies for heart pathology.