抗人 CRCP 抗体对
01AB02963
CGRP receptor component (CRCP) is an intracellular peripheral membrane protein required for the full signaling activity of the calcitonin gene-related peptide (CGRP) receptor complex. It directly supports the functional receptor, which is composed of the calcitonin receptor-like receptor (CLR) and RAMP1, by enabling efficient downstream Gs-protein coupling and cAMP production. CRCP is localized to the cytoplasm and plasma membrane, where it acts as an essential modulator that translates CGRP binding into a complete cellular response. Through its regulation of CGRP signaling, CRCP influences physiological processes such as vasodilation, nociception, and cardiovascular homeostasis.
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技术参数
- 靶点基因名
- CRCP
- 蛋白别名
- CGRP receptor component; CRCP
- UniProt
- O75575
- 物种
- Human
产品详情
- 靶点名称
- CRCP
- 蛋白名称
- CGRP receptor component
- 蛋白别名
- DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17
- 靶点基因名
- CRCP
- UniProt
- O75575
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CGRP receptor component (CRCP) is an intracellular peripheral membrane protein required for the full signaling activity of the calcitonin gene-related peptide (CGRP) receptor complex. It directly supports the functional receptor, which is composed of the calcitonin receptor-like receptor (CLR) and RAMP1, by enabling efficient downstream Gs-protein coupling and cAMP production. CRCP is localized to the cytoplasm and plasma membrane, where it acts as an essential modulator that translates CGRP binding into a complete cellular response. Through its regulation of CGRP signaling, CRCP influences physiological processes such as vasodilation, nociception, and cardiovascular homeostasis.