抗人 CRACD 抗体对
01AB02392
Capping protein inhibiting regulator of actin dynamics (CRACD) is a cytosolic protein enriched in epithelial tissues that maintains cytoskeletal organization and cell integrity. It functions by inhibiting barbed-end actin-capping proteins, thereby promoting actin polymerization and regulating cell-cell adhesion. CRACD is expressed across various organs, including the gastrointestinal tract and brain, where it supports structural stability. Clinically, CRACD is recognized as a putative tumor suppressor. Alterations in the CRACD gene have been linked to testicular sex cord-stromal neoplasms, such as Leydig cell tumors. Disruption of its function is proposed to impair epithelial barrier integrity and contribute to oncogenic transformation and tumor progression, highlighting its role as a regulator of actin dynamics in both physiological and pathological contexts.
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技术参数
- 靶点基因名
- CRACD
- 基因别名
- CRAD; KIAA1211
- 蛋白别名
- capping protein inhibiting regulator of actin dynamics; CRACD
- UniProt
- Q6ZU35
- 物种
- Human
产品详情
- 靶点名称
- CRACD
- 蛋白名称
- capping protein inhibiting regulator of actin dynamics
- 蛋白别名
- Capping protein-inhibiting regulator of actin dynamics; Cancer-related regulator of actin dynamics
- 靶点基因名
- CRACD
- 基因别名
- CRAD; KIAA1211
- UniProt
- Q6ZU35
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Capping protein inhibiting regulator of actin dynamics (CRACD) is a cytosolic protein enriched in epithelial tissues that maintains cytoskeletal organization and cell integrity. It functions by inhibiting barbed-end actin-capping proteins, thereby promoting actin polymerization and regulating cell-cell adhesion. CRACD is expressed across various organs, including the gastrointestinal tract and brain, where it supports structural stability. Clinically, CRACD is recognized as a putative tumor suppressor. Alterations in the CRACD gene have been linked to testicular sex cord-stromal neoplasms, such as Leydig cell tumors. Disruption of its function is proposed to impair epithelial barrier integrity and contribute to oncogenic transformation and tumor progression, highlighting its role as a regulator of actin dynamics in both physiological and pathological contexts.