抗人 CPSF73 抗体对
01AB02961
Cleavage and polyadenylation specificity factor subunit 3 (CPSF73) is a zinc-dependent metallo-beta-lactamase endonuclease that serves as the catalytic core of the mammalian cleavage and polyadenylation specificity factor (CPSF) complex. It forms an obligate heterodimer with CPSF100 and associates with symplekin to execute the 3'-end cleavage of pre-mRNAs and histone pre-mRNAs, a critical step in transcript maturation and transcription termination. The enzyme's active site coordinates zinc ions essential for its RNA endonuclease activity. Given its fundamental role in mRNA processing and cell viability, CPSF73 is investigated as a potential therapeutic target in various cancers where its inhibition can disrupt tumor cell proliferation.
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技术参数
- 靶点基因名
- CPSF3
- 基因别名
- CPSF73
- 蛋白别名
- cleavage and polyadenylation specific factor 3; CPSF73
- UniProt
- Q9UKF6
- 物种
- Human
产品详情
- 靶点名称
- CPSF73
- 蛋白名称
- cleavage and polyadenylation specific factor 3
- 蛋白别名
- Cleavage and polyadenylation specificity factor subunit 3; Cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF 73 kDa subunit; mRNA 3'-end-processing endonuclease CPSF-73
- 靶点基因名
- CPSF3
- 基因别名
- CPSF73
- UniProt
- Q9UKF6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cleavage and polyadenylation specificity factor subunit 3 (CPSF73) is a zinc-dependent metallo-beta-lactamase endonuclease that serves as the catalytic core of the mammalian cleavage and polyadenylation specificity factor (CPSF) complex. It forms an obligate heterodimer with CPSF100 and associates with symplekin to execute the 3'-end cleavage of pre-mRNAs and histone pre-mRNAs, a critical step in transcript maturation and transcription termination. The enzyme's active site coordinates zinc ions essential for its RNA endonuclease activity. Given its fundamental role in mRNA processing and cell viability, CPSF73 is investigated as a potential therapeutic target in various cancers where its inhibition can disrupt tumor cell proliferation.