人 CPSF6 抗体对
01AB01461
Cleavage and polyadenylation specific factor 6 (CPSF6) is a 68 kDa protein that serves as a core component of the cleavage factor Im (CFIm) complex, which is essential for the 3' end processing of pre-mRNA, specifically for cleavage and polyadenylation required to generate mature mRNA molecules. CPSF6 binds to RNA early in the assembly of the 3' end processing complex, facilitating the recruitment of other processing factors and regulating alternative polyadenylation by recognizing UGUA elements in the 3' untranslated region of pre-mRNAs, thereby influencing mRNA diversity and export. Structurally, CPSF6 contains domains similar to spliceosomal proteins and forms a heterotetramer with NUDT21/CPSF5 and CPSF7 or CPSF6 itself. Disease associations include a link to lung cancer and carnitine-acylcarnitine translocase deficiency, though the mechanistic details remain under investigation. Notably, CPSF6 also interacts with the HIV-1 capsid, promoting viral integration into transcriptionally active chromatin, which is critical for efficient HIV-1 infection and highlights its potential role in viral pathogenesis and as a therapeutic target.
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技术参数
- 靶点基因名
- CPSF6
- 基因别名
- CFIM68
- 蛋白别名
- cleavage and polyadenylation specific factor 6; CPSF6
- UniProt
- Q16630
- 物种
- Human
产品详情
- 靶点名称
- CPSF6
- 蛋白名称
- cleavage and polyadenylation specific factor 6
- 蛋白别名
- Cleavage and polyadenylation specificity factor subunit 6; Cleavage and polyadenylation specificity factor 68 kDa subunit; CPSF 68 kDa subunit; Cleavage factor Im complex 68 kDa subunit; CFIm68; Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII-4/7
- 靶点基因名
- CPSF6
- 基因别名
- CFIM68
- UniProt
- Q16630
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cleavage and polyadenylation specific factor 6 (CPSF6) is a 68 kDa protein that serves as a core component of the cleavage factor Im (CFIm) complex, which is essential for the 3' end processing of pre-mRNA, specifically for cleavage and polyadenylation required to generate mature mRNA molecules. CPSF6 binds to RNA early in the assembly of the 3' end processing complex, facilitating the recruitment of other processing factors and regulating alternative polyadenylation by recognizing UGUA elements in the 3' untranslated region of pre-mRNAs, thereby influencing mRNA diversity and export. Structurally, CPSF6 contains domains similar to spliceosomal proteins and forms a heterotetramer with NUDT21/CPSF5 and CPSF7 or CPSF6 itself. Disease associations include a link to lung cancer and carnitine-acylcarnitine translocase deficiency, though the mechanistic details remain under investigation. Notably, CPSF6 also interacts with the HIV-1 capsid, promoting viral integration into transcriptionally active chromatin, which is critical for efficient HIV-1 infection and highlights its potential role in viral pathogenesis and as a therapeutic target.