人 CORO1C 抗体对
01AB01667
Coronin 1C (CORO1C) is an actin-binding protein belonging to the WD repeat protein family, characterized by multiple WD repeat domains that facilitate the formation of multiprotein complexes and are involved in essential cellular processes such as cytoskeletal organization, cell cycle progression, signal transduction, and apoptosis. CORO1C plays a specialized role in regulating branched actin structures, particularly at endosomal membranes, where it confines actin to specific regions to control endosome fission and receptor sorting, thereby influencing cell shape, adhesion, and intracellular trafficking. In terms of disease association, CORO1C is frequently upregulated in several cancers, including colorectal, hepatocellular, and gastric cancers, where its overexpression correlates with increased tumor invasiveness, metastasis, and poor patient prognosis, highlighting its potential as a biomarker for aggressive cancer phenotypes.
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技术参数
- 靶点基因名
- CORO1C
- 基因别名
- CRN2; CRNN4
- 蛋白别名
- coronin 1C; CORO1C
- UniProt
- Q9ULV4
- 物种
- Human
产品详情
- 靶点名称
- CORO1C
- 蛋白名称
- coronin 1C
- 蛋白别名
- Coronin-1C; Coronin-3; hCRNN4
- 靶点基因名
- CORO1C
- 基因别名
- CRN2; CRNN4
- UniProt
- Q9ULV4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Coronin 1C (CORO1C) is an actin-binding protein belonging to the WD repeat protein family, characterized by multiple WD repeat domains that facilitate the formation of multiprotein complexes and are involved in essential cellular processes such as cytoskeletal organization, cell cycle progression, signal transduction, and apoptosis. CORO1C plays a specialized role in regulating branched actin structures, particularly at endosomal membranes, where it confines actin to specific regions to control endosome fission and receptor sorting, thereby influencing cell shape, adhesion, and intracellular trafficking. In terms of disease association, CORO1C is frequently upregulated in several cancers, including colorectal, hepatocellular, and gastric cancers, where its overexpression correlates with increased tumor invasiveness, metastasis, and poor patient prognosis, highlighting its potential as a biomarker for aggressive cancer phenotypes.