抗人 CORO1A 抗体对
01AB02957
Coronin 1A (CORO1A) is a WD-repeat, actin-binding protein predominantly expressed in leukocytes, where it is essential for actin cytoskeletal remodeling and cell migration. It forms a beta-propeller structure that interacts with F-actin, influencing Rac1 signaling, T-cell receptor-induced calcium flux, and thymic egress. CORO1A is critical for the survival and homeostasis of naive T cells and also contributes to phagosome dynamics in macrophages. Clinically, loss-of-function mutations in CORO1A are a well-established cause of autosomal recessive T-cell immunodeficiency, characterized by a severe reduction in peripheral T cells and increased susceptibility to viral and opportunistic infections.
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技术参数
- 靶点基因名
- CORO1A
- 基因别名
- CORO1
- 蛋白别名
- coronin 1A; CORO1A
- UniProt
- P31146
- 物种
- Human
产品详情
- 靶点名称
- CORO1A
- 蛋白名称
- coronin 1A
- 蛋白别名
- Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
- 靶点基因名
- CORO1A
- 基因别名
- CORO1
- UniProt
- P31146
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Coronin 1A (CORO1A) is a WD-repeat, actin-binding protein predominantly expressed in leukocytes, where it is essential for actin cytoskeletal remodeling and cell migration. It forms a beta-propeller structure that interacts with F-actin, influencing Rac1 signaling, T-cell receptor-induced calcium flux, and thymic egress. CORO1A is critical for the survival and homeostasis of naive T cells and also contributes to phagosome dynamics in macrophages. Clinically, loss-of-function mutations in CORO1A are a well-established cause of autosomal recessive T-cell immunodeficiency, characterized by a severe reduction in peripheral T cells and increased susceptibility to viral and opportunistic infections.