人 CoREST 抗体对
01AB00377
REST corepressor 1 (RCOR1) is a well-conserved protein that plays a crucial role in neural cell differentiation. It is an essential component of the BHC complex, which represses transcription of neuron-specific genes in non-neuronal cells by binding to the C-terminal domain of REST. RCOR1 functions as a molecular beacon for recruiting machinery that imposes silencing across chromosomal intervals and is involved in histone demethylation and deacetylation. It is downregulated at birth and expressed in various tissues, including the brain, liver, and hematopoietic cells. RCOR1 has been implicated in several diseases, including Joubert Syndrome 1 and medulloblastoma. In cancer, RCOR1 has been associated with tumor progression in various types, such as oral squamous cell carcinoma, breast cancer, and glioblastoma, where it may influence cancer stem cell-like properties and angiogenesis.
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技术参数
- 靶点基因名
- RCOR1
- 基因别名
- KIAA0071; RCOR
- 蛋白别名
- REST corepressor 1; CoREST
- UniProt
- Q9UKL0
- 物种
- Human
产品详情
- 靶点名称
- CoREST
- 蛋白名称
- REST corepressor 1
- 蛋白别名
- REST corepressor 1; Protein CoREST
- 靶点基因名
- RCOR1
- 基因别名
- KIAA0071; RCOR
- UniProt
- Q9UKL0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
REST corepressor 1 (RCOR1) is a well-conserved protein that plays a crucial role in neural cell differentiation. It is an essential component of the BHC complex, which represses transcription of neuron-specific genes in non-neuronal cells by binding to the C-terminal domain of REST. RCOR1 functions as a molecular beacon for recruiting machinery that imposes silencing across chromosomal intervals and is involved in histone demethylation and deacetylation. It is downregulated at birth and expressed in various tissues, including the brain, liver, and hematopoietic cells. RCOR1 has been implicated in several diseases, including Joubert Syndrome 1 and medulloblastoma. In cancer, RCOR1 has been associated with tumor progression in various types, such as oral squamous cell carcinoma, breast cancer, and glioblastoma, where it may influence cancer stem cell-like properties and angiogenesis.